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Fizazi, Karim [Author]; Retz, Margitta [Author]; Petrylak, Daniel P. [Author]; Goh, Jeffrey C. [Author]; Perez-Gracia, Jose [Author]; Lacombe, Louis [Author]; Zschäbitz, Stefanie [Author]; Burotto, Mauricio [Author]; Mahammedi, Hakim [Author]; Gravis, Gwenaelle [Author]; Bastos, Diogo Assed [Author]; McCune, Steven L. [Author]; Limón, Juan Carlos Vázquez [Author]; Kwan, Edmond M. [Author]; Castellano, Daniel [Author]; Fléchon, Aude [Author]; Saad, Fred [Author]; Grimm, Marc-Oliver [Author]; Shaffer, David R. [Author]; Armstrong, Andrew J. [Author]; Bhagavatheeswaran, Prabhu [Author]; Amin, Neha P. [Author]; Ünsal-Kaçmaz, Keziban [Author]; Wang, Xuya [Author]; [...]

Nivolumab plus rucaparib for metastatic castration-resistant prostate cancer : results from the phase 2 CheckMate 9KD trial

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17 August 2022

Published in: Journal for ImmunoTherapy of Cancer ; 10(2022), 8, Artikel-ID e004761, Seite 1-14
Ünsal-Kaçmaz, Keziban; Sancar, Aziz

Quaternary Structure of ATR and Effects of ATRIP and Replication Protein A on Its DNA Binding and Kinase Activities

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Informa UK Limited, 2004

Published in: Molecular and Cellular Biology, 24 (2004) 3, Seite 1292-1300
Tan, Xingzhi; Lam, My-Hanh; Ragunathan, Shoba; Unsal-Kacmaz, Keziban; Loganzo, Frank

Abstract 2757: Antibody-drug conjugate payloads induce markers of immunogenic cell death in cancer cells

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American Association for Cancer Research (AACR), 2018

Published in: Cancer Research, 78 (2018) 13_Supplement, Seite 2757-2757
Ünsal-Kaçmaz, Keziban; Mullen, Thomas E.; Kaufmann, William K.; Sancar, Aziz

Coupling of Human Circadian and Cell Cycles by the Timeless Protein

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Informa UK Limited, 2005

Published in: Molecular and Cellular Biology, 25 (2005) 8, Seite 3109-3116
Sancar, Aziz; Lindsey-Boltz, Laura A.; Ünsal-Kaçmaz, Keziban; Linn, Stuart

Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints

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Annual Reviews, 2004

Published in: Annual Review of Biochemistry, 73 (2004) 1, Seite 39-85
Ünsal-Kaçmaz, Keziban; Makhov, Alexander M.; Griffith, Jack D.; Sancar, Aziz

Preferential binding of ATR protein to UV-damaged DNA

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Proceedings of the National Academy of Sciences, 2002

Published in: Proceedings of the National Academy of Sciences, 99 (2002) 10, Seite 6673-6678
Ünsal-Kaçmaz, Keziban; Makhov, Alexander M.; Griffith, Jack D.; Sancar, Aziz

Preferential Binding of ATR Protein to UV-Damaged DNA

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National Academy of Sciences, 2002

Published in: Proceedings of the National Academy of Sciences of the United States of America, 99 (2002) 10, Seite 6673-6678
Falk, Matthew D.; Liu, Wei; Bolaños, Ben; Unsal-Kacmaz, Keziban; Klippel, Anke; Grant, Stephan; Brooun, Alexei; Timofeevski, Sergei

Enzyme kinetics and distinct modulation of the protein kinase N family of kinases by lipid activators and small molecule inhibitors

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Portland Press Ltd., 2014

Published in: Bioscience Reports, 34 (2014) 2
Unsal-Kacmaz, Keziban; Ragunathan, Shoba; Rosfjord, Edward; Dann, Stephen; Upeslacis, Erik; Grillo, Mary; Hernandez, Richard; Mack, Fiona; Klippel, Anke

The interaction of PKN3 with RhoC promotes malignant growth

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Wiley, 2012

Published in: Molecular Oncology, 6 (2012) 3, Seite 284-298
Ünsal-Kaçmaz, Keziban; Chastain, Paul D.; Qu, Ping-Ping; Minoo, Parviz; Cordeiro-Stone, Marila; Sancar, Aziz; Kaufmann, William K.

The Human Tim/Tipin Complex Coordinates an Intra-S Checkpoint Response to UV That Slows Replication Fork Displacement

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Informa UK Limited, 2007

Published in: Molecular and Cellular Biology, 27 (2007) 8, Seite 3131-3142
Sausen, Mark; Baden, Jonathan F.; Kalinava, Natallia; Wang, Xuya; Li, Jun; Anguiano, Esperanza; Unsal-Kacmaz, Keziban; Wind-Rotolo, Megan; Quinn, Katie; Green, George

Complementary detection of genomic alterations in metastatic castration-resistant prostate cancer (mCRPC) from CheckMate 9KD through analyses of tumor tissue and plasma DNA

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American Society of Clinical Oncology (ASCO), 2021

Published in: Journal of Clinical Oncology, 39 (2021) 15_suppl, Seite 5038-5038
Emmanuel, Natasha; Bernfeld, Elyssa; Ragunathan, Shoba; Wang, Fang; Shan, Qin; Giannakou, Andreas; Huser, Nanni; Jin, Guixian; Myers, Jeremy; Unsal-Kacmaz, Keziban; Abraham, Robert T.

Abstract A10: Exploring the interplay between the purinosome, a multienzyme, purine biosynthetic machine, and the Rheb-mTORC1 signaling axis

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American Association for Cancer Research (AACR), 2020

Published in: Molecular Cancer Research, 18 (2020) 10_Supplement, Seite A10-A10
Emmanuel, Natasha; Ragunathan, Shoba; Shan, Qin; Wang, Fang; Giannakou, Andreas; Huser, Nanni; Jin, Guixian; Myers, Jeremy; Abraham, Robert T.; Unsal-Kacmaz, Keziban

Purine Nucleotide Availability Regulates mTORC1 Activity through the Rheb GTPase

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Elsevier BV, 2017

Published in: Cell Reports, 19 (2017) 13, Seite 2665-2680
Nikolaishvili-Feinberg, Nana; Jenkins, G. Scott; Nevis, Kathleen R.; Staus, Dean P.; Scarlett, Cameron O.; Ünsal-Kaçmaz, Keziban; Kaufmann, William K.; Cordeiro-Stone, Marila

Ubiquitylation of Proliferating Cell Nuclear Antigen and Recruitment of Human DNA Polymerase η

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American Chemical Society (ACS), 2008

Published in: Biochemistry, 47 (2008) 13, Seite 4141-4150
Heffernan, Timothy P.; Ünsal-Kaçmaz, Keziban; Heinloth, Alexandra N.; Simpson, Dennis A.; Paules, Richard S.; Sancar, Aziz; Cordeiro-Stone, Marila; Kaufmann, William K.

Cdc7-Dbf4 and the Human S Checkpoint Response to UVC

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Elsevier BV, 2007

Published in: Journal of Biological Chemistry, 282 (2007) 13, Seite 9458-9468
Tomita, Yoshihiko; Kobayashi, Ko; Kimura, Go; Oya, Mototsugu; Uemura, Hirotsugu; Nishiyama, Hiroyuki; Galsky, Matthew D; Nasroulah, Federico; Collette, Sandra; Broughton, Edward; Ünsal-Kaçmaz, Keziban; Kamisuki, Yukinori; Bajorin, Dean F

Adjuvant nivolumab versus placebo following radical surgery for high-risk muscle-invasive urothelial carcinoma: a subgroup analysis of Japanese patients enrolled in the phase 3 CheckMate 274 trial

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Oxford University Press (OUP), 2023

Published in: Japanese Journal of Clinical Oncology, 53 (2023) 1, Seite 16-25
Kemp, Michael G.; Akan, Zafer; Yilmaz, Seçil; Grillo, Mary; Smith-Roe, Stephanie L.; Kang, Tae-Hong; Cordeiro-Stone, Marila; Kaufmann, William K.; Abraham, Robert T.; Sancar, Aziz; Ünsal-Kaçmaz, Keziban

Tipin-Replication Protein A Interaction Mediates Chk1 Phosphorylation by ATR in Response to Genotoxic Stress

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Elsevier BV, 2010

Published in: Journal of Biological Chemistry, 285 (2010) 22, Seite 16562-16571
Galsky, Matt D.; Bajorin, Dean F.; Witjes, J. Alfred; Gschwend, Jürgen E.; Tomita, Yoshihiko; Nasroulah, Federico; Li, Jun; Collette, Sandra; Pérez-Valderrama, Begoña; Grimm, Marc-Oliver; Appleman, Leonard Joseph; Gravis, Gwenaelle; Necchi, Andrea; Ye, Dingwei; Stenner, Frank; Wind-Rotolo, Megan; Zhang, Joshua; Unsal-Kacmaz, Keziban

Analysis of disease-free survival in CheckMate 274 by PD-L1 combined positive score and tumor proportion score

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American Society of Clinical Oncology (ASCO), 2022

Published in: Journal of Clinical Oncology, 40 (2022) 6_suppl, Seite 491-491
Hilton, John; Cristea, Mihaela; Postel-Vinay, Sophie; Baldini, Capucine; Voskoboynik, Mark; Edenfield, William; Shapiro, Geoffrey I.; Cheng, Michael L.; Vuky, Jacqueline; Corr, Bradley; Das, Sharmila; Apfel, Abraham; Xu, Ke; Kozicki, Martin; Ünsal-Kaçmaz, Keziban; Hammell, Amy; Wang, Guan; Ravindran, Palanikumar; Kollia, Georgia; Esposito, Oriana; Coker, Shodeinde; Diamond, Jennifer R.

BMS-986158, a Small Molecule Inhibitor of the Bromodomain and Extraterminal Domain Proteins, in Patients with Selected Advanced Solid Tumors: Results from a Phase 1/2a Trial

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MDPI AG, 2022

Published in: Cancers, 14 (2022) 17, Seite 4079
Fizazi, Karim; González Mella, Pablo; Castellano, Daniel; Minatta, Jose Nicolas; Rezazadeh, Arash; Shaffer, David R.; Vazquez Limon, Juan Carlos; Sánchez López, Héctor Manuel; Armstrong, Andrew J.; Horvath, Lisa; Dzik, Carlos; Amin, Neha P.; Li, Jia; Unsal-Kacmaz, Keziban; Retz, Margitta; Saad, Fred; Petrylak, Daniel Peter; Pachynski, Russell Kent

CheckMate 9KD Arm B final analysis: Efficacy and safety of nivolumab plus docetaxel for chemotherapy-naïve metastatic castration-resistant prostate cancer

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American Society of Clinical Oncology (ASCO), 2021

Published in: Journal of Clinical Oncology, 39 (2021) 6_suppl, Seite 12-12

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