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Heimburg, Tino [Author] ; Sippl, Wolfgang [Degree supervisor]; Dobner, Bodo [Degree supervisor]; Jung, Manfred [Degree supervisor]

Struktur-basiertes Design und Synthese von Inhibitoren der schistosomalen Histondesacetylase 8 : neue Ansatzpunkte für die Therapie der Bilharziose

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Halle, Saale: Universitäts- und Landesbibliothek Sachsen-Anhalt, 2015
Pagliazzo, Lucile [Author]; Caby, Stéphanie [Author]; Lancelot, Julien [Author]; Salomé-Desnoulez, Sophie [Author]; Saliou, Jean-Michel [Author]; Heimburg, Tino [Author]; Chassat, Thierry [Author]; Cailliau, Katia [Author]; Sippl, Wolfgang [Author]; Vicogne, Jérôme [Author]; Pierce, Raymond J. [Author]

Histone deacetylase 8 interacts with the GTPase SmRho1 in Schistosoma mansoni

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2021

Published in: Public Library of Science: PLoS neglected tropical diseases ; 15(2021), 11, Artikel-ID e0009503
Darwish, Salma [Author]; Ghazy, Ehab Mohamed Elbassiony [Author]; Heimburg, Tino [Author]; Herp, Daniel [Author]; Zeyen, Patrik René [Author]; Salem-Altintas, Rabia [Author]; Ridinger, Johannes [Author]; Robaa, Dina [Author]; Schmidtkunz, Karin [Author]; Erdmann, Frank [Author]; Schmidt, Matthias [Author]; Romier, Christophe [Author]; Jung, Manfred [Author]; Oehme, Ina [Author]; Sippl, Wolfgang [Author]

Design, synthesis and biological characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with anti-neuroblastoma activity

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7 July 2022

Published in: International journal of molecular sciences ; 23(2022), 14, Artikel-ID 7535, Seite 1-31
Vaca, Hugo Rolando [Author]; Celentano, Ana María [Author]; Toscanini, María Agustina [Author]; Heimburg, Tino [Author]; Ghazy, Ehab [Author]; Zeyen, Patrik [Author]; Hauser, Alexander-Thomas [Author]; Oliveira, Guilherme [Author]; Elissondo, María Celina [Author]; Jung, Manfred [Author]; Sippl, Wolfgang [Author]; Camicia, Federico [Author]; Rosenzvit, Mara Cecilia [Author]

The potential for histone deacetylase (HDAC) inhibitors as cestocidal drugs

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2021

Published in: Public Library of Science: PLoS neglected tropical diseases ; 15(2021), 3, Artikel-ID e0009226
Vaca, Hugo Rolando [Author]; Celentano, Ana María [Author]; Toscanini, María Agustina [Author]; Heimburg, Tino [Author]; Ghazy, Ehab [Author]; Zeyen, Patrik [Author]; Hauser, Alexander-Thomas [Author]; Oliveira, Guilherme [Author]; Elissondo, María Celina [Author]; Jung, Manfred [Author]; Sippl, Wolfgang [Author]; Camicia, Federico [Author]; Rosenzvit, Mara Cecilia [Author]

The potential for histone deacetylase (HDAC) inhibitors as cestocidal drugs

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Lawrence, Kan.: Public Library of Science, 2021

Published in: PLoS neglected tropical diseases ; 15, 3 (2021), e0009226
Marek, Martin [Author]; Shaik, Tajith B. [Author]; Heimburg, Tino [Author]; Chakrabarti, Alokta [Author]; Lancelot, Julien [Author]; Ramos-Morales, Elizabeth [Author]; Da Veiga, Cyrielle [Author]; Kalinin, Dmitrii [Author]; Melesina, Jelena [Author]; Robaa, Dina [Author]; Schmidtkunz, Karin [Author]; Suzuki, Takayoshi [Author]; Holl, Ralph [Author]; Ennifar, Eric [Author]; Pierce, Raymond J. [Author]; Jung, Manfred [Author]; Sippl, Wolfgang [Author]; Romier, Christophe [Author]

Characterization of histone deacetylase 8 (HDAC8) selective inhibition reveals specific active site structural and functional determinants

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October 22, 2018

Published in: Journal of medicinal chemistry ; 61(2018), 22, Seite 10000-10016
Pagliazzo, Lucile; Caby, Stéphanie; Lancelot, Julien; Salomé-Desnoulez, Sophie; Saliou, Jean-Michel; Heimburg, Tino; Chassat, Thierry; Cailliau, Katia; Sippl, Wolfgang; Vicogne, Jérôme; Pierce, Raymond J.

Histone deacetylase 8 interacts with the GTPase SmRho1 in Schistosoma mansoni

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Public Library of Science (PLoS), 2021

Published in: PLOS Neglected Tropical Diseases, 15 (2021) 11, Seite e0009503
Kolbinger, Fiona R.; Koeneke, Emily; Ridinger, Johannes; Heimburg, Tino; Müller, Michael; Bayer, Theresa; Sippl, Wolfgang; Jung, Manfred; Gunkel, Nikolas; Miller, Aubry K.; Westermann, Frank; Witt, Olaf; Oehme, Ina

The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines

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Springer Science and Business Media LLC, 2018

Published in: Archives of Toxicology, 92 (2018) 8, Seite 2649-2664
Kannan, Srinivasaraghavan; Melesina, Jelena; Hauser, Alexander-Thomas; Chakrabarti, Alokta; Heimburg, Tino; Schmidtkunz, Karin; Walter, Alexandra; Marek, Martin; Pierce, Raymond J.; Romier, Christophe; Jung, Manfred; Sippl, Wolfgang

Discovery of Inhibitors of Schistosoma mansoni HDAC8 by Combining Homology Modeling, Virtual Screening, and in Vitro Validation

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American Chemical Society (ACS), 2014

Published in: Journal of Chemical Information and Modeling, 54 (2014) 10, Seite 3005-3019
Darwish, Salma; Ghazy, Ehab; Heimburg, Tino; Herp, Daniel; Zeyen, Patrik; Salem-Altintas, Rabia; Ridinger, Johannes; Robaa, Dina; Schmidtkunz, Karin; Erdmann, Frank; Schmidt, Matthias; Romier, Christophe; Jung, Manfred; Oehme, Ina; Sippl, Wolfgang

Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity

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MDPI AG, 2022

Published in: International Journal of Molecular Sciences, 23 (2022) 14, Seite 7535
Vaca, Hugo Rolando; Celentano, Ana María; Toscanini, María Agustina; Heimburg, Tino; Ghazy, Ehab; Zeyen, Patrik; Hauser, Alexander-Thomas; Oliveira, Guilherme; Elissondo, María Celina; Jung, Manfred; Sippl, Wolfgang; Camicia, Federico; Rosenzvit, Mara Cecilia

The potential for histone deacetylase (HDAC) inhibitors as cestocidal drugs

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Public Library of Science (PLoS), 2021

Published in: PLOS Neglected Tropical Diseases, 15 (2021) 3, Seite e0009226
Marek, Martin; Shaik, Tajith B.; Heimburg, Tino; Chakrabarti, Alokta; Lancelot, Julien; Ramos-Morales, Elizabeth; Da Veiga, Cyrielle; Kalinin, Dmitrii; Melesina, Jelena; Robaa, Dina; Schmidtkunz, Karin; Suzuki, Takayoshi; Holl, Ralph; Ennifar, Eric; Pierce, Raymond J.; Jung, Manfred; Sippl, Wolfgang; Romier, Christophe

Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants

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American Chemical Society (ACS), 2018

Published in: Journal of Medicinal Chemistry, 61 (2018) 22, Seite 10000-10016
Shen, Jing; Najafi, Sara; Stäble, Sina; Fabian, Johannes; Koeneke, Emily; Kolbinger, Fiona R.; Wrobel, Jagoda K.; Meder, Benjamin; Distel, Martin; Heimburg, Tino; Sippl, Wolfgang; Jung, Manfred; Peterziel, Heike; Kranz, Dominique; Boutros, Michael; Westermann, Frank; Witt, Olaf; Oehme, Ina

A kinome-wide RNAi screen identifies ALK as a target to sensitize neuroblastoma cells for HDAC8-inhibitor treatment

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Springer Science and Business Media LLC, 2018

Published in: Cell Death & Differentiation, 25 (2018) 12, Seite 2053-2070
Heimburg, Tino; Kolbinger, Fiona R.; Zeyen, Patrik; Ghazy, Ehab; Herp, Daniel; Schmidtkunz, Karin; Melesina, Jelena; Shaik, Tajith Baba; Erdmann, Frank; Schmidt, Matthias; Romier, Christophe; Robaa, Dina; Witt, Olaf; Oehme, Ina; Jung, Manfred; Sippl, Wolfgang

Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity

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American Chemical Society (ACS), 2017

Published in: Journal of Medicinal Chemistry, 60 (2017) 24, Seite 10188-10204
Heimburg, Tino; Chakrabarti, Alokta; Lancelot, Julien; Marek, Martin; Melesina, Jelena; Hauser, Alexander-Thomas; Shaik, Tajith B.; Duclaud, Sylvie; Robaa, Dina; Erdmann, Frank; Schmidt, Matthias; Romier, Christophe; Pierce, Raymond J.; Jung, Manfred; Sippl, Wolfgang

Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis

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American Chemical Society (ACS), 2016

Published in: Journal of Medicinal Chemistry, 59 (2016) 6, Seite 2423-2435
Lechner, Severin; Malgapo, Martin Ian P.; Grätz, Christian; Steimbach, Raphael R.; Baron, Agnes; Rüther, Patrick; Nadal, Simon; Stumpf, Carmen; Loos, Christina; Ku, Xin; Prokofeva, Polina; Lautenbacher, Ludwig; Heimburg, Tino; Würf, Vivian; Meng, Chen; Wilhelm, Mathias; Sippl, Wolfgang; Kleigrewe, Karin; Pauling, Josch K.; Kramer, Karl; Miller, Aubry K.; Pfaffl, Michael W.; Linder, Maurine E.; Kuster, Bernhard;

Author Correction: Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target

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Springer Science and Business Media LLC, 2022

Published in: Nature Chemical Biology, 18 (2022) 8, Seite 913-913
Lechner, Severin; Malgapo, Martin Ian P.; Grätz, Christian; Steimbach, Raphael R.; Baron, Agnes; Rüther, Patrick; Nadal, Simon; Stumpf, Carmen; Loos, Christina; Ku, Xin; Prokofeva, Polina; Lautenbacher, Ludwig; Heimburg, Tino; Würf, Vivian; Meng, Chen; Wilhelm, Mathias; Sippl, Wolfgang; Kleigrewe, Karin; Pauling, Josch K.; Kramer, Karl; Miller, Aubry K.; Pfaffl, Michael W.; Linder, Maurine E.; Kuster, Bernhard;

Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target

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Springer Science and Business Media LLC, 2022

Published in: Nature Chemical Biology, 18 (2022) 8, Seite 812-820

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