> Issues
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Comparison of extracellular vesicles from induced pluripotent stem cell-derived brain cells Gabriela Xavier, Alexander Navarrete Santos, Carla Hartmann, Marcos L. Santoro, Nicole Flegel, Jessica Reinsch, Annika Majer, Toni Ehrhardt, Jenny Pfeifer, Andreas Simm, Thomas Hollemann, Sintia I. Belangero, Dan Rujescu, Matthias Jung
2024
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In Vitro functionality and endurance of GMP-compliant point-of-care BCMA.CAR-T cells at different timepoints of cryopreservation Genqiao Jiang, Brigitte Neuber, Angela Hückelhoven-Krauss, Uta E. Höpken, Yuntian Ding, David Sedloev, Lei Wang, Avinoam Reichman, Franziska Eberhardt, Martin Wermke, Armin Rehm, Carsten Müller-Tidow, Anita Schmitt and Michael Schmitt
23 January 2024
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Transcriptomic changes in the myocardium and coronary artery of donation after circulatory death hearts following ex vivo machine perfusion Lars Saemann, Kristin Wächter, Adrian-Iustin Georgevici, Sabine Pohl, Fabio Hoorn, Gábor Veres, Sevil Korkmaz-Icöz, Matthias Karck, Andreas Simm, Gábor Szabó
19 January 2024
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Toxicity of water-soluble D-g-PNIPAM polymers in a complex with chemotherapy drugs and mechanism of their action in vitro Svitlana Prylutska, Anna Grebinyk, Stanislav Ponomarenko, Defne Gövem, Vasyl Chumachenko, Nataliya Kutsevol, Mykola Petrovsky, Uwe Ritter, Marcus Frohme, Jacek Piosik and Yuriy Prylutskyy
2024
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HTK vs. HTK-N for coronary endothelial protection during hypothermic, oxygenated perfusion of hearts donated after circulatory death Lars Saemann, Kristin Wächter, Nitin Gharpure, Sabine Pohl, Fabio Hoorn, Sevil Korkmaz-Icöz, Matthias Karck, Gábor Veres, Andreas Simm and Gábor Szabó
13 February 2024
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Molecular long-term analysis of the GMMG-HD4 trial in multiple myeloma$patterns of Association of Chromosomal Aberrations with response and proliferation determining survival in selecting treatments in view of limited resources in low- and middle-income countries Anja Seckinger, Hans Salwender, Hans Martin, Christof Scheid, Thomas Hielscher, Uta Bertsch, Manuela Hummel, Anna Jauch, Wolfgang Knauf, Martina Emde-Rajaratnam, Susanne Beck, Kai Neben, Jan Dührig, Walter Lindemann, Ingo G. H. Schmidt-Wolf, Mathias Hänel, Igor W. Blau, Katja Weisel, Niels Weinhold, Marc S. Raab, Hartmut Goldschmidt, Mimi Choon-Quinones and Dirk Hose
11 June 2024
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Differential expression of CKLF-like MARVEL transmembrane domain-containing protein 6 and programmed cell death ligand 1 as prognostic biomarkers in Upper Tract Urothelial Carcinoma Said Kdimati, Clemens Christoph, Änne Glass, Nadja Engel, Desiree-Louise Dräger, Claudia Maletzki, Anne-Sophie Becker and Annette Zimpfer
March 2024
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The utility of miniaturized adsorbers in exploring the cellular and molecular effects of blood purification a pilot study with a focus on immunoadsorption in multiple sclerosis Andreas Körtge, Anne Breitrück, Sandra Doß, Jacqueline Hofrichter, Sophie-Charlotte Nelz, Horst Krüsemann, Reinhold Wasserkort, Brit Fitzner, Michael Hecker, Steffen Mitzner and Uwe Klaus Zettl
March 2024
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Suppression PCR-based selective enrichment sequencing for pathogen and antimicrobial resistance detection on cell-free DNA in sepsis-A targeted, blood culture-independent approach for rapid pathogen and resistance diagnostics in septic patients Mirko Sonntag, Vanessa K. Elgeti, Yevhen Vainshtein, Lucca Jenner, Jan Mueller, Thorsten Brenner, Sebastian O. Decker and Kai Sohn
17 May 2024
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Laccase-treated polystyrene surfaces with caffeic acid, dopamine, and L-3,4-dihydroxyphenylalanine substrates facilitate the proliferation of melanocytes and embryonal carcinoma cells NTERA-2 by Hanluo Li, Martin Wilhelm, Christina Marie Baumbach, Michael C. Hacker, Michael Szardenings, Klaus Rischka, Andreas Koenig, Ellen Schulz-Kornas, Florian Fuchs, Jan Christoph Simon, Bernd Lethaus and Vuk Savković
2024
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The dual role of neutrophil extracellular traps (NETs) in sepsis and ischemia-reperfusion injury comparative analysis across murine models Antonia Kiwit, Yuqing Lu, Moritz Lenz, Jasmin Knopf, Christoph Mohr, Yannick Ledermann, Michaela Klinke-Petrowsky, Laia Pagerols Raluy, Konrad Reinshagen, Martin Herrmann, Michael Boettcher and Julia Elrod
April 2024
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Protein kinase D plays a crucial role in maintaining cardiac homeostasis by regulating post-translational modifications of myofilament proteins Melissa Herwig, Merima Begovic, Heidi Budde, Simin Delalat, Saltanat Zhazykbayeva, Marcel Sieme, Luca Schneider, Kornelia Jaquet, Andreas Mügge, Ibrahim Akin, Ibrahim El-Battrawy, Jens Fielitz and Nazha Hamdani
28 February 2024
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Non-invasive biomarkers for diagnosis, risk prediction, and therapy guidance of glomerular kidney diseases a comprehensive review by Lorenzo Catanese, Harald Rupprecht, Tobias B. Huber, Maja T. Lindenmeyer, Felicitas E. Hengel, Kerstin Amann, Ralph Wendt, Justyna Siwy, Harald Mischak and Joachim Beige
2024
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Establishment of a machine learning model for the risk assessment of perineural invasion in head and neck squamous cell carcinoma Christopher Weusthof, Sebastian Burkart, Karl Semmelmayer, Fabian Stögbauer, Bohai Feng, Karam Khorani, Sebastian Bode, Peter Plinkert, Karim Plath and Jochen Hess
18 May 2023
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Evaluation of the novel sepsis biomarker host-derived delta-like canonical notch Ligand 1 - a secondary analysis of 405 patients suffering from inflammatory or infectious diseases Tobias Hölle, Patrick Rehn, Konstantinos Leventogiannis, Antigone Kotsaki, Theodora Kanni, Nikolaos Antonakos, Christos Psarrakis, Georgia Damoraki, Judith Schenz, Felix C.F. Schmitt, Florian Uhle, Markus A. Weigand, Evangelos J. Giamarellos-Bourboulis and Maximilian Dietrich
2023
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Desorption kinetics evaluation for the development of validated desorption electrospray ionization-mass spectrometric assays for drug quantification in tissue sections Margaux Fresnais, Siwen Liang, Deniz Seven, Nevena Prodanovic, Julia Sundheimer, Walter E. Haefeli, Jürgen Burhenne and Rémi Longuespée
9 May 2023
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The Impact of Nε-Acryloyllysine Piperazides on the Conformational Dynamics of Transglutaminase 2 Andreas Heerwig, Alfred Kick, Paul Sommerfeld, Sophia Eimermacher, Frederick Hartung, Markus Laube, Dietmar Fischer, Hans-Jürgen Pietzsch, Jens Pietzsch, Reik Löser, Michael Mertig, Markus Pietsch, and Robert Wodtke
2023
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Multiomics based association mapping in wheat reveals genetic architecture of quality and allergenic related proteins Khaoula El Hassouni, Muhammad Afzal, Kim A. Steige, Malte Sielaff, Valentina Curella, Manjusha Neerukonda, Stefan Tenzer, Detlef Schuppan, Carl Friedrich Horst Longin and Patrick Thorwarth
2023
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HLA-E and its soluble form as indicators of a sex-specific immune response in patients with rral squamous cell carcinoma Anne Radermacher, Michael Fehrenz, Tamara Bellin, Carolina Claßen, Laura Möller, Ann-Kristin Struckmeier, Mathias Wagner, Philipp Wartenberg, Julius Moratin, Christian Freudlsperger, Kolja Freier and Dominik Horn
24 November 2023
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Bioactive constituents of verbena officinalis alleviate inflammation and enhance killing efficiency of natural killer cells Xiangdong Dai, Xiangda Zhou, Rui Shao, Renping Zhao, Archana K. Yanamandra, Zhimei Xing, Mingyu Ding, Junhong Wang, Tao Liu, Qi Zheng, Peng Zhang, Han Zhang, Yi Wang, Bin Qu and Yu Wang
2023
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Depletion of Ly6G-expressing neutrophilic cells leads to altered peripheral T-cell homeostasis and thymic development in neonatal mice Jessica Rühle, Marco Ginzel, Stefanie Dietz, Julian Schwarz, Trim Lajqi, Sandra Beer-Hammer, Christian F. Poets, Christian Gille and Natascha Köstlin-Gille
24 April 2023
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Depolarization and hyperexcitability of cortical motor neurons after spinal cord injury associates with reduced HCN channel activity Bruno Benedetti, Lara Bieler, Christina Erhardt-Kreutzer, Dominika Jakubecova, Ariane Benedetti, Maximilian Reisinger, Dominik Dannehl, Christian Thome, Maren Engelhardt and Sebastien Couillard-Despres
1 March 2023
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Antibody-based and cell therapies for advanced mastocytosis established and novel concepts Peter Valent, Cem Akin, Michel Arock, Karoline V. Gleixner, Hildegard Greinix, Olivier Hermine, Hans-Peter Horny, Daniel Ivanov, Alberto Orfao, Werner Rabitsch, Andreas Reiter, Axel Schulenburg, Karl Sotlar, Wolfgang R. Sperr and Celalettin Ustun
12 October 2023
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Adipose-derived mesenchymal stem cells protect endothelial cells from hypoxic injury by suppressing terminal UPR in vivo and in vitro Michael Keese, Jiaxing Zheng, Kaixuan Yan, Karen Bieback, Benito A. Yard, Prama Pallavi, Christoph Reissfelder, Mark Andreas Kluth, Martin Sigl and Vugar Yugublu
6 December 2023
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S-Adenosylhomocysteine is a useful metabolic factor in the early prediction of septic disease progression and death in critically Ill patients a prospective cohort study Franz-Simon Centner, Jochen J. Schoettler, Kathrin Brohm, Sonani Mindt, Evelyn Jäger, Bianka Hahn, Tanja Fuderer, Holger A. Lindner, Verena Schneider-Lindner, Joerg Krebs, Michael Neumaier and Manfred Thiel
9 August 2023
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The role of sensory innervation in homeostatic and injury-induced corneal epithelial renewal Konstantin Feinberg, Kiana Tajdaran, Kaveh Mirmoeini, Simeon C. Daeschler, Mario A. Henriquez, Katelyn E. Stevens, Chilando M. Mulenga, Arif Hussain, Pedram Hamrah, Asim Ali, Tessa Gordon, Gregory H. Borschel
August 2023
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A combination of the immunotherapeutic drug anti-programmed death 1 with lenalidomide enhances specific T cell immune responses against acute myeloid Leukemia cells Barbara-ann Guinn, Patrick J. Schuler, Hubert Schrezenmeier, Susanne Hofmann, Johanna Weiss, Christiane Bulach, Marlies Götz and Jochen Greiner
2023
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An all-green photo-electrochemical biosensor using microalgae immobilized on eco-designed lignin-based screen-printed electrodes to detect sustainable nanoherbicides Amina Antonacci, Valeria Frisulli, Lucas Bragança Carvalho, Leonardo Fernandes Fraceto, Bruno Miranda, Luca De Stefano, Udo Johanningmeier, Maria Teresa Giardi, Viviana Scognamiglio
2023
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Flagellin-induced immune response in human-induced pluripotent stem cell-derived cardiomyocytes Goekhan Yuecel, Xiaobo Zhou, Linda Terkatz, Angela Wendel, Julius Reinhardt, Ibrahim El-Battrawy, Katherine Sattler, Lukas Cyganek, Jochen Utikal, Harald Langer, Ruediger Scharf, Daniel Duerschmied and Ibrahim Akin
2023
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Polymorphisms within autophagy-related genes as susceptibility biomarkers for multiple myeloma a meta-analysis of three large cohorts and functional characterization Esther Clavero, José Manuel Sanchez-Maldonado, Angelica Macauda, Rob Ter Horst, Belém Sampaio-Marques, Artur Jurczyszyn, Alyssa Clay-Gilmour, Angelika Stein, Michelle A.T. Hildebrandt, Niels Weinhold, Gabriele Buda, Ramón García-Sanz, Waldemar Tomczak, Ulla Vogel, Andrés Jerez, Daria Zawirska, Marzena Wątek, Jonathan N. Hofmann, Stefano Landi, John J. Spinelli, Aleksandra Butrym, Abhishek Kumar, Joaquín Martínez-López, Sara Galimberti, María Eugenia Sarasquete, Edyta Subocz, Elzbieta Iskierka-Jażdżewska, Graham G. Giles, Malwina Rybicka-Ramos, Marcin Kruszewski, Niels Abildgaard, Francisco García Verdejo, Pedro Sánchez Rovira, Miguel Inacio da Silva Filho, Katalin Kadar, Małgorzata Razny, Wendy Cozen, Matteo Pelosini, Manuel Jurado, Parveen Bhatti, Marek Dudzinski, Agnieszka Druzd-Sitek, Enrico Orciuolo, Yang Li, Aaron D. Norman, Jan Maciej Zaucha, Rui Manuel Reis, Miroslaw Markiewicz, Juan José Rodríguez Sevilla, Vibeke Andersen, Krzysztof Jamroziak, Kari Hemminki, Sonja I. Berndt, Vicent Rajkumar, Grzegorz Mazur, Shaji K. Kumar, Paula Ludovico, Arnon Nagler, Stephen J. Chanock, Charles Dumontet, Mitchell J. Machiela, Judit Varkonyi, Nicola J. Camp, Elad Ziv, Annette Juul Vangsted, Elizabeth E. Brown, Daniele Campa, Celine M. Vachon, Mihai G. Netea, Federico Canzian, Asta Försti and Juan Sainz
2023
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The single-dose application of interleukin-4 ameliorates secondary brain damage in the early phase after moderate experimental traumatic brain injury in mice Johannes Walter, Jannis Mende, Samuel Hutagalung, Obada T. Alhalabi, Martin Grutza, Guoli Zheng, Thomas Skutella, Andreas Unterberg, Klaus Zweckberger and Alexander Younsi
2023
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Human α-defensin 5 1-9 and human β-defensin 2 improve metabolic parameters and gut barrier function in mice fed a western-style diet Louisa Filipe Rosa, Andreas Rings, Iris Stolzer, Louis Koeninger, Jan Wehkamp, Julia Beisner, Claudia Günther, Peter Nordkild, Benjamin A. H. Jensen, Stephan C. Bischoff
2023
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Correlation between circulating miR-16, miR-29a, miR-144 and miR-150, and the radiotherapy response and survival of non-small-cell lung cancer patients Matthias Bache, Frauke Kadler, Olivia Struck, Daniel Medenwald, Christian Ostheimer, Antje Güttler, Jacqueline Keßler, Matthias Kappler, Anne Riemann, Oliver Thews, Barbara Seliger, Dirk Vordermark
2023
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Correction Bay et al. functional characterization of the solute carrier LAT-1 (SLC7A5/SLC3A2) in human brain capillary endothelial cells with rapid UPLC-MS/MS quantification of intracellular isotopically labelled L-leucine. Int. J. Mol. Sci. 2022, 23, 3637 Cindy Bay, Gzona Bajraktari-Sylejmani, Walter E. Haefeli, Jürgen Burhenne, Johanna Weiss and Max Sauter
6 March 2023
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Integrated microarray-based data analysis of miRNA expression profiles identification of novel biomarkers of cisplatin-resistance in testicular germ cell tumours Jan Roška, João Lobo, Danica Ivovic, Lenka Wachsmannová, Thomas Mueller, Rui Henrique, Carmen Jerónimo, Miroslav Chovanec, Dana Jurkovicová
2023
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Galectin-3 and blood group binding properties, effects on plasma levels, and consequences for prognostic performance Carolin Pozder, Elles M. Screever, A. Rogier van der Velde, Herman H. Silljé, Janne Suwijn, Saskia de Rond, Marcus E. Kleber, Graciela Delgado, Jan Jacob Schuringa, Wiek H. van Gilst, Wouter C. Meijers, Winfried März and Rudolf A. de Boer
23 February 2023
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3D visualization, skeletonization and branching analysis of blood vessels in angiogenesis Vignesh Ramakrishnan, Rebecca Schönmehl, Annalena Artinger, Lina Winter, Hendrik Böck, Stephan Schreml, Florian Gürtler, Jimmy Daza, Volker H. Schmitt, Andreas Mamilos, Pablo Arbelaez, Andreas Teufel, Tanja Niedermair, Ondrej Topolcan, Marie Karlíková, Samuel Sossalla, Christoph B. Wiedenroth, Markus Rupp and Christoph Brochhausen
23 April 2023
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Detection and monitoring of tumor-derived mutations in circulating tumor DNA using the UltraSEEK lung panel on the MassARRAY system in metastatic non-small cell lung cancer patients Paul van der Leest, Melanie Janning, Naomi Rifaela, Maria L. Aguirre Azpurua, Jolanthe Kropidlowski, Sonja Loges, Nicolas Lozano, Alexander Sartori, Darryl Irwin, Pierre-Jean Lamy, T. Jeroen N. Hiltermann, Harry J. M. Groen, Klaus Pantel, Léon C. van Kempen, Harriet Wikman and Ed Schuuring
2023
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Different involvement of vimentin during invasion by listeria monocytogenes at the blood-brain and the blood-cerebrospinal fluid barriers in vitro Franjo Banovic, Sandrin Schulze, Mobarak Abu Mraheil, Torsten Hain, Trinad Chakraborty, Véronique Orian-Rousseau, Selina Moroniak, Christel Weiss, Hiroshi Ishikawa, Horst Schroten, Rüdiger Adam and Christian Schwerk
26 October 2022
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Patient-derived tumor organoids for guidance of personalized drug therapies in recurrent glioblastoma Miriam Ratliff, Hichul Kim, Hao Qi, Minsung Kim, Bosung Ku, Daniel Dominguez Azorin, David Hausmann, Rajiv K. Khajuria, Areeba Patel, Elena Maier, Loic Cousin, Arnaud Ogier, Felix Sahm, Nima Etminan, Lukas Bunse, Frank Winkler, Victoria El-Khoury, Michael Platten and Yong-Jun Kwon
12 June 2022
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Retrospective natural history study of RPGR-related cone-and cone-rod dystrophies while expanding the mutation spectrum of the disease Marco Nassisi, Giuseppe De Bartolo, Saddek Mohand-Said, Christel Condroyer, Aline Antonio, Marie-Elise Lancelot, Kinga Bujakowska, Vasily Smirnov, Thomas Pugliese, John Neidhardt, José-Alain Sahel, Christina Zeitz and Isabelle Audo
2022
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99mTc-HDP labeling - a non-destructive method for real-time surveillance of the osteogenic differentiation potential of hMSC during ongoing cell cultures Jakob Hofmann, Kai Borcherding, Karsten Thiel, Thomas Lingner, Ulrike Sommer, Uwe Haberkorn, Tim Niklas Bewersdorf, Gerhard Schmidmaier and Tobias Grossner
14 December 2022
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Circulating miR-200 family and CTCs in metastatic breast cancer before, during, and after a new line of systemic treatment Chiara Fischer, Andrey Turchinovich, Manuel Feisst, Fabian Riedel, Kathrin Haßdenteufel, Philipp Scharli, Andreas D. Hartkopf, Sara Y. Brucker, Laura Michel, Barbara Burwinkel, Andreas Schneeweiss, Markus Wallwiener and Thomas M. Deutsch
23 August 2022
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RNA and protein determinants mediate differential binding of miRNAs by a viral suppressor of RNA silencing thus modulating antiviral immune responses in plants by Robert Pertermann, Ralph Peter Golbik, Selvaraj Tamilarasan, Torsten Gursinsky, Selma Gago-Zachert, Vitantonio Pantaleo, Iris Thondorf, Sven-Erik Behrens
2022
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Platelet inhibition by low-dose acetylsalicylic acid reduces neuroinflammation in an animal model of multiple sclerosis by Anna Vogelsang, Susann Eichler, Niklas Huntemann, Lars Masanneck, Hannes Böhnlein, Lisa Schüngel, Alice Willison, Karin Loser, Bernhard Nieswandt, Beate E. Kehrel, Alexander Zarbock, Kerstin Göbel and Sven G. Meuth
2022
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Combining recombinase-mediated cassette exchange strategy with quantitative proteomic and phosphoproteomic analyses to inspect intracellular functions of the tumor suppressor Galectin-4 in colorectal cancer cells Malwina Michalak, Viola Golde, Dominik Helm, Herbert Kaltner, Johannes Gebert and Jürgen Kopitz
8 June 2022
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Pharmacological probes to validate biomarkers for analgesic drug development Johannes van Niel, Petra Bloms-Funke, Ombretta Caspani, Jose Maria Cendros, Luis Garcia-Larrea, Andrea Truini, Irene Tracey, Sonya C. Chapman, Nicolás Marco-Ariño, Iñaki F. Troconiz, Keith Phillips, Nanna Brix Finnerup, André Mouraux and Rolf-Detlef Treede
27 July 2022
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Molecular subtyping of invasive breast cancer using a PAM50-based multigene expression test-comparison with molecular-like subtyping by tumor grade/immunohistochemistry and influence on oncologist’s decision on systemic therapy in a real-world setting Ramona Erber, Miriam Angeloni, Robert Stöhr, Michael P. Lux, Daniel Ulbrich-Gebauer, Enrico Pelz, Agnes Bankfalvi, Kurt W. Schmid, Robert F.H. Walter, Martina Vetter, Christoph Thomssen, Doris Mayr, Frederick Klauschen, Peter Sinn, Karl Sotlar, Katharina Stering, Albrecht Stenzinger, Marius Wunderle, Peter A. Fasching, Matthias W. Beckmann, Oliver Hoffmann, Rainer Kimmig, Nadia Harbeck, Rachel Wuerstlein, Fulvia Ferrazzi and Arndt Hartmann
5 August 2022
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Non-invasive assessment of locally overexpressed human adenosine 2A receptors in the heart of transgenic mice by Daniel Gündel, Thu Hang Lai, Sladjana Dukic-Stefanovic, Rodrigo Teodoro, Winnie Deuther-Conrad, Magali Toussaint, Klaus Kopka, Rareş-Petru Moldovan, Peter Boknik, Britt Hofmann, Ulrich Gergs, Joachim Neumann and Peter Brust
2022
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Correlation of immunological and molecular profiles with response to crizotinib in alveolar soft part sarcoma an exploratory study related to the EORTC 90101 “CREATE” trial Che-Jui Lee, Elodie Modave, Bram Boeckx, Bernd Kasper, Steinar Aamdal, Michael G. Leahy, Piotr Rutkowski, Sebastian Bauer, Maria Debiec-Rychter, Raf Sciot, Diether Lambrechts, Agnieszka Wozniak and Patrick Schöffski
19 May 2022
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Intramyocardial inflammation after COVID-19 vaccination an endomyocardial biopsy-proven case series by Christian Baumeier, Ganna Aleshcheva, Dominik Harms, Ulrich Gross, Christian Hamm, Birgit Assmus, Ralf Westenfeld, Malte Kelm, Spyros Rammos, Philip Wenzel, Thomas Münzel, Albrecht Elsässer, Mudather Gailani, Christian Perings, Alae Bourakkadi, Markus Flesch, Tibor Kempf, Johann Bauersachs, Felicitas Escher and Heinz-Peter Schultheiss
2022
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Specific targeting of antiapoptotic Bcl-2 proteins as a radiosensitizing approach in solid tumors Benjamin Sobol, Osama Azzam Nieto, Emily Lara Eberlein, Anna-Lena Scherr, Lars Ismail, Annika Kessler, Luisa Nader, Maximilian Schwab, Paula Hoffmeister, Nathalie Schmitt, Dirk Jäger, Stefan Welte, Katharina Seidensaal, Petros Christopoulos, Christoph Heilig, Katharina Kriegsmann, Stefan Fröhling, Mark Kriegsmann, Jochen Hess and Bruno Christian Köhler
16 July 2022
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Design, synthesis and biological characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with anti-neuroblastoma activity Salma Darwish, Ehab Ghazy, Tino Heimburg, Daniel Herp, Patrik Zeyen, Rabia Salem-Altintas, Johannes Ridinger, Dina Robaa, Karin Schmidtkunz, Frank Erdmann, Matthias Schmidt, Christophe Romier, Manfred Jung, Ina Oehme and Wolfgang Sippl
7 July 2022
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Human mesenchymal stromal cells do not cause radioprotection of head-and-neck squamous cell carcinoma Alexander Rühle, Marie Lies, Maren Strack, Ramon Lopez Perez, Birgit Bieber, Andreas R. Thomsen, Peter Bronsert, Peter E. Huber, Jochen Hess, Andreas Knopf, Patrick Wuchter, Anca-Ligia Grosu and Nils H. Nicolay
12 July 2022
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Inactivation of osteoblast PKC signaling reduces cortical bone mass and density and aggravates renal osteodystrophy in mice with chronic kidney disease on high phosphate diet Ariane Zaloszyc, Philippe Choquet, Amira Sayeh, Maria Bartosova, Betti Schaefer, Ulrike Huegel, Gaëlle Aubertin-Kirch, Christopher Healy, François Severac, Sébastien Rizzo, Georges Boivin, Franz Schaefer, Michel Fischbach, Justine Bacchetta, Seiamak Bahram and Claus Peter Schmitt
8 June 2022
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In vivo biocompatibility investigation of an injectable calcium carbonate (vaterite) as a bone substitute including compositional analysis via SEM-EDX technology by Ronald E. Unger, Sanja Stojanovic, Laura Besch, Said Alkildani, Romina Schröder, Ole Jung, Caroline Bogram, Oliver Görke [und 3 weitere]
February-1 2022
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Nutritional calcium supply dependent calcium balance, bone calcification and calcium isotope ratios in rats Jeremy Rott, Eva Teresa Toepfer, Maria Bartosova, Ana Kolevica, Alexander Heuser, Michael Rabe, Geert Behets, Patrick C. D’Haese, Viktoria Eichwald, Manfred Jugold, Ivan Damgov, Sotirios G. Zarogiannis, Rukshana Shroff, Anton Eisenhauer and Claus Peter Schmitt
14 July 2022
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Differential expression of serum extracellular vesicle miRNAs in multiple sclerosis disease-stage specificity and relevance to pathophysiology Nagiua Cuomo-Haymour, Giorgio Bergamini, Giancarlo Russo, Luka Kulic, Irene Knuesel, Roland Martin, André Huss, Hayrettin Tumani, Markus Otto and Christopher R. Pryce
2022
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Prodynorphin and proenkephalin in cerebrospinal fluid of sporadic Creutzfeldt-Jakob disease Samir Abu-Rumeileh, Peggy Barschke, Patrick Oeckl, Simone Baiardi, Angela Mammana, Andrea Mastrangelo, Mhd Rami Al Shweiki, Petra Steinacker, Anna Ladogana, Sabina Capellari, Markus Otto and Piero Parchi
2022
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Elevated oxytocin receptor blood concentrations predict higher risk for, more, and earlier 24-month hospital readmissions after in-patient detoxification in males with alcohol use disorder Christiane Mühle, Massimiliano Mazza, Christian Weinland, Claudia von Zimmermann, Patrick Bach, Falk Kiefer, Valery Grinevich, Iulia Zoicas, Johannes Kornhuber and Bernd Lenz
1 September 2022
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Synthesis, molecular docking and biological characterization of pyrazine linked 2-aminobenzamides as new class I selective histone deacetylase (HDAC) inhibitors with anti-leukemic activity Hany S. Ibrahim, Mohamed Abdelsalam, Yanira Zeyn, Matthes Zessin, Al-Hassan M. Mustafa, Marten A. Fischer , Patrik Zeyen, Ping Sun, Emre F. Bülbül, Anita Vecchio, Frank Erdmann, Matthias Schmidt, Dina Robaa, Cyril Barinka, Christophe Romier, Mike Schutkowski, Oliver H. Krämer and Wolfgang Sippl
2022
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Neurochemical Monitoring of Traumatic Brain Injury by the Combined Analysis of Plasma Beta-Synuclein, NfL, and GFAP in Polytraumatized Patients by Rebecca Halbgebauer, Steffen Halbgebauer, Patrick Oeckl, Petra Steinacker, Eberhard Weihe, Martin K- H. Schafer, Francesco Roselli, Florian Gebhard and Markus Otto
2022
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Comparison of FACS and PCR for detection of BCMA-CAR-T cells Avinoam Reichman, Alexander Kunz, Jara J. Joedicke, Uta E. Höpken, Anna Keib, Brigitte Neuber, David Sedloev, Lei Wang, Genqiao Jiang, Angela Hückelhoven-Krauss, Franziska Eberhardt, Carsten Müller-Tidow, Martin Wermke, Armin Rehm, Michael Schmitt and Anita Schmitt
14 January 2022
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Functional characterization of the aolute carrier LAT-1 (SLC7A5/SLC2A3) in human brain capillary endothelial cells with rapid UPLC-MS/MS quantification of intracellular isotopically labelled L-Leucine Cindy Bay, Gzona Bajraktari-Sylejmani, Walter E. Haefeli, Jürgen Burhenne, Johanna Weiss and Max Sauter
26 March 2022
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Effects of environmental conditions on nephron number modeling maternal disease and epigenetic regulation in renal development Lars Fuhrmann, Saskia Lindner, Alexander-Thomas Hauser, Clemens Höse, Oliver Kretz,Clemens D. Cohen, Maja T. Lindenmeyer, Wolfgang Sippl, Manfred Jung, Tobias B. Huber and Nicola Wanner
2021
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Structure-based design, docking and binding free energy calculations of A366 derivatives as spindlin1 inhibitors Chiara Luise, Dina Robaa, Pierre Regenass, David Maurer, Dmytro Ostrovskyi, Ludwig Seifert,Johannes Bacher, Teresa Burgahn, Tobias Wagner, Johannes Seitz, Holger Greschik, Kwang-Su Park,Yan Xiong, Jian Jin, Roland Schüle, Bernhard Breit, Manfred Jung and Wolfgang Sippl
2021
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PIM1 inhibition affects glioblastoma stem cell behavior and kills glioblastoma stem-like cells Carolin Seifert, Ellen Balz, Susann Herzog, Anna Korolev, Sebastian Gaßmann, Heiko Paland, Matthias A. Fink, Markus Grube, Sascha Marx, Gabriele Jedlitschky, Mladen V. Tzvetkov, Bernhard H. Rauch, Henry W. S. Schroeder and Sandra Bien-Möller
2021
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Refining genotypes and phenotypes in KCNA2-related neurological disorders Jan H. Döring, Julian Schröter, Jerome Jüngling, Saskia Biskup, Kerstin A. Klotz, Thomas Bast, Tobias Dietel, G. Christoph Korenke, Sophie Christoph, Heiko Brennenstuhl, Guido Rubboli, Rikke S. Møller, Gaetan Lesca, Yves Chaix, Stefan Kölker, Georg F. Hoffmann, Johannes R. Lemke and Steffen Syrbe
10 March 2021
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The Thyroid hormone transporter Mct8 restricts Cathepsin-Mediated Thyroglobulin processing in male mice through Thyroid auto-regulatory mechanisms that encompass Autophagy Vaishnavi Venugopalan, Alaa Al-Hashimi, Maren Rehders, Janine Golchert, Vivien Reinecke, Georg Homuth, Uwe Völker, Mythili Manirajah, Adam Touzani, Jonas Weber, Francois Verrey, Eva K. Wirth, Ulrich Schweizer, Heike Heuer, Janine Kirstein
2021
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Analysis of biomechanical parameters of muscle soleus contraction and blood biochemical parameters in rat with chronic glyphosate intoxication and therapeutic use of C60 fullerene Dmytro Nozdrenko, Olga Abramchuk, Svitlana Prylutska, Oksana Vygovska, Vasil Soroca, Kateryna Bogutska, Sergii Khrapatyi, Yuriy Prylutskyy, Peter Scharff and Uwe Ritter
2021
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Enhanced antiviral function of magnesium chloride-modified heparin on a broad spectrum of viruses Kemal Mese, Oskar Bunz, Wolfram Volkwein, Sahithya P. B. Vemulapalli, Wenli Zhang, Sebastian Schellhorn, Kristin Heenemann, Antje Rueckner, Andreas Sing, Thomas W. Vahlenkamp, Anna-Lena Severing, Jian Gao, Malik Aydin, Dominik Jung, Hagen S. Bachmann, Kurt S. Zänker, Ulrich Busch, Armin Baiker, Christian Griesinger and Anja Ehrhardt
2021
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Therapeutic Evaluation of Antibody-Based Targeted Delivery of Interleukin 9 in Experimental Pulmonary Hypertension Baptiste Gouyou, Katja Grün, Anne Kerschenmeyer, Alessandra Villa, Mattia Matasci, Andrea Schrepper, Alexander Pfeil, Laura Bäz, Christian Jung, Christian Schulze, Dario Neri and Marcus Franz
27 March 2021
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Detecting Bacterial Cell Viability in Few µL Solutions from Impedance Measurements on Silicon-Based Biochips Vinayak J. Bhat, Sahitya V. Vegesna, Mahdi Kiani, Xianyue Zhao, Daniel Blaschke, Manja Vogel, Sindy Kluge, Johannes Raff, Uwe Hübner, Ilona Skorupa, Lars Rebohle and Heidemarie Schmidt
29 March 2021
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Lipid droplet biosynthesis impairment through dgat2 inhibition sensitizes mcf7 breast cancer cells to radiation Clelia Nisticò, Francesca Pagliari, Emanuela Chiarella, Joana Fernandes Guerreiro, Maria Grazia Marafioti, Ilenia Aversa, Geraldine Genard, Rachel Hanley, Daniel Garcia-Calderón, Heather Mandy Bond, Maria Mesuraca, Luca Tirinato, Maria Francesca Spadea and Joao Carlos Seco
18 September 2021
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Functional and molecular properties of dyt-sgce myoclonus-dystonia patient-derived striatal medium spiny neurons by Anna Kutschenko, Selma Staege, Karen Grütz, Hannes Glaß, Norman Kalmbach, Thomas Gschwendtberger, Lisa M. Henkel, Johanne Heine, Anne Grünewald, Andreas Hermann, Philip Seibler and Florian Wegner
1 April 2021
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Ex vivo and in vivo analyses of novel 3d-printed bone substitute scaffolds incorporating biphasic calcium phosphate granules for bone regeneration by Franciska Oberdiek, Carlos Ivan Vargas, Patrick Rider, Milijana Batinic, Oliver Görke, Milena Radenković, Stevo Najman, Jose Manuel Baena, Ole Jung and Mike Barbeck
1 April 2021
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Repetitive Elements in Humans Thomas Liehr
19 February 2021
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Epithelial Membrane Protein 2 Suppresses Non-Small Cell Lung Cancer Cell Growth by Inhibition of MAPK Pathway Yunxia Ma, Desiree Charlotte Schröder, Miljana Nenkov, Maryam Noor Rizwan, Mohamed Abubrig, Jürgen Sonnemann, José M. Murrieta-Coxca, Diana M. Morales-Prieto, Martin Westermann, Nikolaus Gaßler and Yuan Chen
14 March 2021
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Hyperlipidemic Conditions Impact Force-Induced Inflammatory Response of Human Periodontal Ligament Fibroblasts Concomitantly Challenged with P. gingivalis-LPS Judit Symmank, Sophie Appel, Jana Asisa Bastian, Isabel Knaup, Jana Marciniak, Christoph-Ludwig Hennig, Annika Döding, Ulrike Schulze-Späte, Collin Jacobs and Michael Wolf
4 June 2021
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Genetic dissection of phosphorus use efficiency in a maize association population under two P levels in the field Dongdong Li, Haoying Wang, Meng Wang, Guoliang Li, Zhe Chen, Willmar L. Leiser, Thea Mi Weiß, Xiaohuan Lu, MingWang, Shaojiang Chen, Fanjun Chen, Lixing Yuan, Tobias Würschum and Wenxin Liu
27 August 2021
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Identification of the key molecular drivers of phosphorus utilization based on host miRNA-mRNA and gut microbiome interactions Siriluck Ponsuksili, Henry Reyer, Frieder Hadlich, Frank Weber, Nares Trakooljul, Michael Oster, Puntita Siengdee, Eduard Muráni, Markus Rodehutscord, Amélia Camarinha-Silva, Jörn Bennewitz and Klaus Wimmers
17 April 2020
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The lack of evidence for an association between cancer biomarker conversion patterns and CTC-Status in patients with metastatic breast cancer Stefan Stefanovic, Thomas M. Deutsch, Sabine Riethdorf, Chiara Fischer, Andreas Hartkopf, Peter Sinn, Manuel Feisst, Klaus Pantel, Michael Golatta, Sara Y. Brucker, Marc Sütterlin, Andreas Schneeweiss, Markus Wallwiener
21 March 2020
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Identification of brain-specific treatment effects in NPC1 disease by focusing on cellular and molecular changes of sphingosine-1-phosphate metabolism Anne Gläser, Franziska Hammerl, Markus H. Gräler, Sina M. Coldewey, Christin Völkner, Moritz J. Frech, Fan Yang, Jiankai Luo, Eric Tönnies, Oliver von Bohlen und Halbach, Nicola Brandt, Diana Heimes, Anna-Maria Neßlauer, Georg Christoph Korenke, Marta Owczarek-Lipska, John Neidhardt, Arndt Rolfs, Andreas Wree, Martin Witt and Anja Ursula Bräuer
2020
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Metabolomic and gene expression studies reveal the diversity, distribution and spatial regulation of the specialized metabolism of yacón (Smallanthus sonchifolius, Asteraceae) Guillermo F. Padilla-González, Evelyn Amrehn, Maximilian Frey, Javier Gómez-Zeledón, Alevtina Kaa, Fernando B. Da Costa and Otmar Spring
26 June 2020
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Does protein glycation impact on the drought-related changes in metabolism and nutritional properties of mature pea (Pisum sativum L.) seeds? Tatiana Leonova, Alexander Tsarev, Kristina Antonova, Maria Vikhnina, Alena Soboleva, Ekaterina Dinastia, Mandy Dorn, Gerd U. Balcke, Christian Ihling, Tatiana Bilova, Andrej Frolov [und 12 weitere]
2020
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(Phospho)proteomic profiling of microsatellite unstable CRC cells reveals alterations in nuclear signaling and cholesterol metabolism caused by frameshift mutation of NMD regulator UPF3A Malwina Michalak, Eva-Maria Katzenmaier, Nina Roeckel, Stefan M. Woerner, Vera Fuchs, Uwe Warnken, Yan P. Yuan, Peer Bork, Gabriele Neu-Yilik, Andreas Kulozik, Magnus von Knebel Doeberitz, Matthias Kloor, Jürgen Kopitz and Johannes Gebert
23 July 2020
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YBX1 indirectly targets heterochromatin-repressed inflammatory response-related apoptosis genes through regulating CBX5 mRNA by Andreas Kloetgen, Sujitha Duggimpudi, Konstantin Schuschel, Kebria Hezaveh, Daniel Picard, Heiner Schaal, Marc Remke, Jan-Henning Klusmann, Arndt Borkhardt, Alice C. McHardy and Jessica I. Hoell
2020
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MiR-519d-3p in Trophoblastic Cells Effects, Targets and Transfer to Allogeneic Immune Cells via Extracellular Vesicles Wittaya Chaiwangyen, José M. Murrieta-Coxca, Rodolfo R. Favaro, Stella M. Photini, Ruby N. Gutiérrez-Samudio, Ekkehard Schleussner, Udo R. Markert, Diana M. Morales-Prieto
14 May 2020
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Sensitivity of rodent microglia to kynurenines in models of epilepsy and inflammation in vivo and in vitro microglia activation is inhibited by kynurenic acid and the synthetic analogue SZR104 Noémi Lajkó, Diana Kata, Melinda Szabó, Adrienne Mátyás, Karolina Dulka, Imre Földesi, Ferenc Fülöp, Karoly Gulya, László Vécsei and András Mihály
2020
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Role of IL-36 Cytokines in the Regulation of Angiogenesis Potential of Trophoblast Cells José M. Murrieta-Coxca, Ruby N. Gutiérrez-Samudio, Heba M. El-Shorafa, Tanja Groten, Sandra Rodríguez-Martínez, Mario E. Cancino-Diaz, Juan C. Cancino-Diaz, Rodolfo R. Favaro, Udo R. Markert and Diana M. Morales-Prieto
30 December 2020
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Expression, regulation and function of microRNA as important players in the transition of MDS to secondary AML and their cross talk to RNA-binding proteins Marcus Bauer, Christoforos Vaxevanis, Nadine Heimer, Haifa Kathrin Al-Ali, Nadja Jaekel, Michael Bachmann, Claudia Wickenhauser and Barbara Seliger
2020
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Compression bioreactor-based mechanical loading induces mobilization of Human bone Marrow-Derived Mesenchymal stromal cells into collagen scaffolds in vitro Carolina Gamez, Barbara Schneider-Wald, Karen Bieback, Andy Schuette, Sylvia Büttner, Mathias Hafner, Norbert Gretz and Markus L. Schwarz
4 November 2020
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Strong signs for a weak wall in tricuspid aortic valve associated aneurysms and a role for osteopontin in bicuspid aortic valve associated aneurysms Christian Stern, Bernhard Scharinger, Adrian Tuerkcan, Clemens Nebert, Teresa Mimler, Ulrike Baranyi, Christian Doppler, Thomas Aschacher, Martin Andreas, Marie-Elisabeth Stelzmueller, Marek Ehrlich, Alexandra Graf, Guenther Laufer, David Bernhard, Barbara Messner
2019
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Oxazole-bridged combretastatin A-4 derivatives with tethered hydroxamic acids structure-activity relations of new inhibitors of HDAC and/or tubulin function Florian Schmitt, Lisa Chiara Gosch, Alexandra Dittmer, Matthias Rothemund, Thomas Mueller, Rainer Schobert, Bernhard Biersack, Andrea Volkamer and Michael Höpfner
2019
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Challenges and contradictions of metal nano-particle applications for radio-sensitivity enhancement in cancer therapy Eva Pagáčová, Lenka Štefančíková, Franz Schmidt-Kaler, Georg Hildenbrand, Tomáš Vičar, Daniel Depeš, Jin-Ho Lee, Felix Bestvater, Sandrine Lacombe, Erika Porcel, Stéphane Roux, Frederik Wenz, Olga Kopečná, Iva Falková, Michael Hausmann and Martin Falk
30 January 2019
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Causes and consequences of a glutamine induced normoxic HIF1 activity for the tumor metabolism by Matthias Kappler, Ulrike Pabst, Claus Weinholdt, Helge Taubert, Swetlana Rot, Tom Kaune, Johanna Kotrba, Martin Porsch, Antje Güttler, Matthias Bache, Knut Krohn, Fabian Bull, Anne Riemann, Claudia Wickenhauser, Barbara Seliger, Johannes Schubert, Bilal Al-Nawas, Oliver Thews, Ivo Grosse, Dirk Vordermark and Alexander W. Eckert
2019
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Chromosomal evolution and evolutionary relationships of Lebiasina Species Characiformes, Lebiasinidae Francisco de Menezes Cavalcante Sassi, Ezequiel Aguiar de Oliveira, Luiz Antonio Carlos Bertollo, Mauro Nirchio, Terumi Hatanaka, Manoela Maria Ferreira Marinho, Orlando Moreira-Filho, Rouben Aroutiounian, Thomas Liehr, Ahmed B. H. Al-Rikabi and Marcelo de Bello Cioffi
2019
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Matrix metalloproteinase-3 is key effector of TNF-α-induced collagen degradation in skin Ursula Mirastschijski, Blaž Lups̆e, Kathrin Maedler, Bhavishya Sarma, Arlo Radtke, Gazanfer Belge, Martina Dorsch, Dirk Wedekind, Lisa J. McCawley, Gabriele Boehm, Ulrich Zier, Kazuhiro Yamamoto, Sørge Kelm and Magnus S. Agren
October 2019