Rezvani Boroujeni, Samaneh
[Author]
;
Schmidt, Christoph
[Degree supervisor];
Janshoff, Andreas
[Other];
Heussinger, Claus
[Other];
Müller, Marcus
[Other];
Klumpp, Stefan
[Other];
Neef, Andreas
[Other]
Mechanical and biochemical stimulation of suspended cells in a microfluidic device probed with dual optical tweezers
University thesis:
Dissertation, Georg-August-Universität Göttingen, 2017
Footnote:
Description:
Cells communicate with their environment through biochemical and mechanical interactions. They can respond to stimuli by undergoing shape- and, in some situations, volume changes. Key determinants of the mechanical response of a cell are the viscoelastic properties of the actomyosin cortex, effective surface tension, and osmotic pressure. It is challenging to measure the mechanical response of cells while changing environmental conditions. We here demonstrate the use of a novel microfluidic device with integrated hydrogel micro-windows to change solution conditions for cells suspended by op...