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Komarov, Ilya [Author] ; Lührmann, Reinhard [Degree supervisor]; Lührmann, Reinhard [Other]; Ficner, Ralf [Other]

Investigation of the 3D structure of the human activated spliceosome by cryo-electron microscopy

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  • Media type: E-Book; Thesis
  • Title: Investigation of the 3D structure of the human activated spliceosome by cryo-electron microscopy
  • Contributor: Komarov, Ilya [Author]; Lührmann, Reinhard [Degree supervisor]; Lührmann, Reinhard [Other]; Ficner, Ralf [Other]
  • Published: Göttingen, 2017
  • Extent: 1 Online-Ressource; Illustrationen, Diagramme
  • Language: English
  • Identifier:
  • Keywords: Hochschulschrift
  • Origination:
  • University thesis: Dissertation, Georg-August-Universität Göttingen, 2017
  • Footnote:
  • Description: The spliceosome is a highly dynamic megadalton ribonucleoprotein (RNP) complex that catalyses the removal of introns from eukaryotic precursor messenger RNA (pre mRNA) in two consecutive transesterification reactions. The spliceosome is assembled de novo on each pre-mRNA intron by the sequential recruitment of five RNA protein complexes (snRNPs) and numerous non snRNP factors in a dynamic manner, driven by numerous DExH/D box ATPases or RNA helicases. After the U1 and U2 snRNPs bind to the 5’ splice site (ss) and branch site (BS) of the pre-mRNA, respectively, the pre formed U4/U6.U5 tri sn...
  • Access State: Open Access