University thesis:
Dissertation, Georg-August-Universität Göttingen, 2017
Footnote:
Description:
Scattering experiments with femtosecond high-intensity free-electron laser pulses provide a new route to macromolecular structure determination without the need for crystallization at low material usage. In these experiments, the X-ray pulses are scattered with high repitition on a stream of identical single biomolecules and the scattered photons are recorded on a pixelized detector. The main challenges in these experiments are the unknown random orientation of the molecule in each shot and the extremely low signal to noise ratio due to the very low expected photon count per scattering imag...