Lambrecht, Felix
[Author]
;
Stark, Holger
[Degree supervisor];
Grubmüller, Helmut
[Other];
Habeck, Michael
[Other];
Tittmann, Kai
[Other];
Adio, Sarah
[Other]
Computational methods for the structure determination of highly dynamic molecular machines by cryo-EM
University thesis:
Dissertation, Georg-August-Universität Göttingen, 2019
Footnote:
Description:
In the last couple of years, electron cryomicroscopy (cryo-EM) has gained of rising importance in the field of structural biology and biophysics. Not only that the routinely achievable resolution of the method has dramatically increased to routinely near-atomic resolution. First and foremost the opportunity to resolve structures which where far beyond the size limit for classical methods such as X-ray crystallography and NMR increased the popularity. These features make cryo-EM also more and more interesting for the pharmaceutical industry. However, certain challenges are being unresolved u...