Published in:Nature Communications ; 8(2017) Artikel-Nummer 2276, 14 Seiten
Language:
English
DOI:
10.1038/s41467-017-02258-w
Identifier:
Origination:
Footnote:
Description:
An understanding of the dynamics of drug binding and unbinding processes is important for drug discovery. Here, the authors give insights into the binding mechanism of small drug-like molecules to human Hsp90 by combining thermodynamics and kinetics studies as well as molecular dynamics simulations.