Footnote:
Includes bibliographical references and index
Description:
BACE : APP processing, and signal transduction in Alzheimer's disease (AD) / Dale E. Bredesen and Edward H. Koo -- Identification of BACE as an AD target / Robert L. Heinrikson and Sukanto Sinha -- BACE biological assays / Alfredo G. Tomasselli and Michael J. Bienkowski -- Peptidic, peptidomimetic, and HTS based BACE inhibitors / James P. Beck and Dustin J. Mergott -- Fragment-based approaches for identification of BACE inhibitors / Andreas Kuglstatter and Michael Hennig -- Structure-based drug design of BACE inhibitors : technical and practical aspects of preparation, 3-dimensional structure, and computational analysis / Felix F. Vajdos, Veer Shanmugasundaram, and Alfredo G. Tomasselli -- Pharmacological models for preclinical testing : from mouse to dog to non-human primates / Jason L. Eriksen, Michael Paul Murphy, and Elizabeth Head -- Adsorption, distribution, metabolism, excretion (ADME), efficacy & toxicology for BACE inhibitors / Ishrut Hussain and Emmanuel Demont -- Clinical trials for disease modifying drugs such as BACE inhibitors / Henry Hsu -- Future strategies for development of novel BACE inhibitors : anti-APP e-site antibody & APP binding small molecule approaches for Alzheimer's disease / Beka Solomon ... [et al.]