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Media type:
Book
Title:
Solid-phase organic synthesis
:
concepts, strategies, and applications
Contains:
Machine generated contents note: Preface.Acknowledgements.Contributors.Part I. Concepts and Strategies.1. Linker Strategies in Modern Solid-Phase Organic Synthesis (Peter J. H. Scott).1.1 Introduction.1.2 Classical Linker Strategies.1.3 Multifunctional Linker Strategies.1.4 Conclusions.2. Colorimetric Tests for Solid-Phase Organic Synthesis (Yan Teng and Patrick H. Toy).2.1 Introduction.2.2 Functional Group Tests.2.3 Conclusions.3. Practical Aspects of Combinatorial Solid-Phase Synthesis (Jan Hlváč, Miroslav Slural and Viktor Krchňák).3.1 Introduction.3.2 Strategies in Combinatorial Solid-Phase Synthesis.3.3 Equipment and Instrumentation.3.4 Characterization and Purification.3.5 Conclusions.3.6 Acknowledgements.4. Diversity-Oriented Synthesis (Kieron M. G. O'Connell, Warren R. J. D. Galloway, Brett M. Ibbeson, Albert Isidro-Llobet, Cornelius J. O'Connor and David R. Spring).4.1 Introduction.4.2 Small Molecules and Biology.4.3 Diversity-Oriented Synthesis, Target-Oriented Synthesis and Combinatorial Chemistry.4.4 Molecular Diversity.4.5 Diversity-oriented Synthesis on Solid-Phase.4.6 Diversity-Oriented Synthesis Around Privileged Scaffolds.4.7 Diversity Linker Units in Solid-Phase Organic Synthesis.4.8 Conclusions.5. Diversity-Oriented Synthesis of Privileged Heterocycles Using Divergent Strategy (Seung Bum Park and Jonghoon Kim).5.1 Introduction.5.2 Divergent Synthesis of Natural Product-Like Polyheterocycles Using a Cyclic-Iminium as a Single Key Intermediate.5.3 Conclusions.6. Chemo- and Regioselectivity Enhancement in Solid-Supported Reactions (Douglas D. Young and Alexander Deiters).6.1 Introduction.6.2 Transition Metal-Mediated Solid-Supported Reactions.6.3 Non-Transition Metal-Mediated Solid-Supported Reactions.6.4 Traceless Cleavage.6.5 Conclusions.Part II. Applications.7. Asymmetric Synthesis on Solid-Support (Baburaj Baskar and Kamal Kumar).7.1 Introduction.7.2 Asymmetric Chemical Transformations of Solid-Supported Substrates.7.3 Asymmetric Transformations Using Bound Chiral Catalysts and Auxiliaries.7.4 Conclusions.8. Recent Advances in Microwave-Assisted Solid-Phase Synthesis of Heterocycles (Prasad Appukkuttan, Vaibhav P. Mehta and Erik Van der Eycken).8.1 Introduction.8.2 Fused 1, 3-Oxazin-6-ones.8.3 Thiazolo[4,5-d]pyrimidine-5,7-diones.8.4 Pyrazoles.8.5 Hsp70 Modulators.8.6 Benzimidazo[2,1-b]quinazolin-12(5H)-ones.8.7 Imidazoles.8.8 1,4-Napthoquinones.8.9 Phthalocyanines.8.10 1,2,3,4-Tetrahydroquinolines.8.11 1,2,3-Triazoles.8.12 2,8-Diaminopurines.8.13 Imidazolidin-4-ones.8.14 Indoles.8.15 1,2,3,4-Tetrahydroquniolines Using a SmI2-Cleavable Linker.8.16 Hydantoins.8.17 Imatinib.8.18 Isoindolines.8.19 2-(Benzothio)imidazo[1,2a]-pyrimidin-5-ones.8.20 2-Aminobenzothiazoles.8.21 Pyrimidines, Phrazoles and Isoxazoles.8.22 Quinolin-2(1H)ones and Coumarins.8.23 Benzofurans.8.24 i-Condensed Purines.8.25 2(1H)-Pyrazinones.8.26 Conclusions.9. Solid-Phase Synthesis of Heterocycles from Peptides and Amino Acids (Zhi Li, Marc Giulianotti, Wenteng Chen, Richard A. Houghten and Yongping Yu).9.1 Introduction.9.2 Synthesis of Various Heterocycles.9.3 Abbeviations.10. Generation of Drug-Like Five-Membered Heterocyclic Libraries Using Disulfide and Merrified Resin (Young-Dae Gong and Taeho Lee).10.1 Introduction.10.2 Solid-Phase Synthesis of Related Thiazole Compounds.10.3 Solid-Phase Synthesis of Benzoxazoles.10.4 Solid-Phase Synthesis of Related Pyrazole Compounds and 1,3,4-Triazoles via a Dithiocarbazate Linker.10.5 Solid-Phase Synthesis of 1,3,4-Oxadiazoles and 1,3,4-Thiadiazoles via Selective Cyclization.10.6 Solid-Phase Synthesis of 1,2,4-Thiadiazoles.10.7 Conclusions.10.8 Abbreviations.11. Recent Advances in Solid-Phase Dipolar Cycloaddition Reactions (Kirsi Harju and Jari Yli-Kauhaluoma).11.1 Introduction.11.2 Solid-Phase Synthesis of Pyrrolidines, Pyrrolines and Pyrroles.11.3 Solid-Phase Synthesis of Pyrazolines and Pyrazoles.11.4 Solid-Phase Synthesis of Imidazoles, 1,2,4-Triazoles and 1,2,3-Triazoles.11.5 Solid-Phase Synthesis of Isoxazolidines, Isoxazolines and Isoxazoles.11.6 Conclusions.12. Sulfones in Solid-Phase Heterocycle Synthesis (Chai Hoon Soh and Yulin Lam).12.1 Introduction.12.2 Linkers.12.3 Conclusions.13. Solid-Phase Organic Radiosynthesis (Raphae͏̈l Hoareau and Peter J. H. Scott).13.1 Introduction.13.2 Solid-Phase Organic Radiosynthesis with Fluorine-18.13.3 Solid-Phase Organic Radiosynthesis with Carbon-11.13.4 Solid-Phase Organic Radiosynthesis with Other Radioisotopes.13.5 Conclusions.14. Solid-Phase Synthesis of Dyes and Their Applications as Sensors and Bioimaging Probes (Marc Vendrell, Hyung-Ho Ha, Sung Chan Lee and Young -Tae Chang).14.1 Introduction.14.2 On-Bead Sensors.14.3 Solid-Phase Approaches in Fluorescent Labeling.14.4 Solid-Phase Derivatization of Fluorescent Scaffolds.14.5 Diversity-Oriented Fluorescent Libraries.14.6 Conclusions.14.7 Acknowledgements.15. Dendritic Molecules on Solid-Support: Solid-Phase Synthesis and Applications (Kerem Goren and Moshe Portnoy).15.1 Introduction.15.2 Synthesis.15.3 Applications of Dendronized Supports.15.4 Conclusions.16. Oligosaccharide Synthesis on Solid, Soluble-Polymer and Tag Supports (Katsunori Tanaka and Koichi Fukase).16.1 Introduciton.16.2 Solid-Phase Methods for Synthesis of Oligosaccharides.16.3 Polymer-Supported and Tag-Assisted Oligosaccharide Synthesis in Solution.16.4 Conclusions.16.5 Acknowledgements.16.6 Abbreviations.Index. .