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Teicher, Beverly A. [Other]

Cancer Drug Resistance

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  • Media type: E-Book
  • Title: Cancer Drug Resistance
  • Contains: Front Matter; The Cycle Between Angiogenesis, Perfusion, and Hypoxia in Tumors; Influence of Tumor pH on Therapeutic Response; Tumor Oxygenation and Treatment Response; Oncogenes and Tumor Suppressor Genes in Therapeutic Resistance; PET Imaging of Response and Resistance to Cancer Therapy; Cancer Stem Cells Implications for Development of More Effective Therapies; Therapeutic Resistance in Leukemia; Tumor Site Implantation and Animal Model Selection in Oncology; In Vivo Resistance; Characteristics of the Metastatic Phenotype; The Microenvironment and Drug Resistance
    Glutathione and Glutathione S -Transferases in Drug ResistanceMetallothioneins in Drug Resistance; Molecular Determinants of Intrinsic Multidrug Resistance in Cancer Cells and Tumors; New and Revised Concepts in Multidrug Resistance; Cisplatin Resistance; Regulation of the Cellular Pharmacology and Cytotoxicity of Cisplatin by Copper Transporters; Resistance To Taxanes; CpG Island Methylation and Drug Resistance; De Novo and Acquired Resistance to Antitumor Alkylating Agents; Resistance to Antiangiogenic Agents; Resistance to Antiestrogens
    Mechanisms of Glucocorticoid Actions and Resistance in Multiple MyelomaHerceptin Resistance; Role of TGF-ß in Tumor Progression and Metastasis; p53-Based Immunotherapy of Cancer; Response and Resistance to Ionizing Radiation; Amplification in DNA Copy Numbers as a Mechanism of Acquired Drug Resistance; Cancer Chemotherapy; Molecular Profiling in Breast Cancer; Tumor Immune Escape Mechanisms; Back Matter
  • Contributor: Teicher, Beverly A. [Other]
  • imprint: Totowa, NJ: Humana Press Inc, 2006
  • Published in: Cancer Drug Discovery and Development
    SpringerLink ; Bücher
  • Extent: Online-Ressource (digital)
  • Language: English
  • DOI: 10.1007/978-1-59745-035-5
  • ISBN: 9781597450355
  • Identifier:
  • RVK notation: XH 3200 : Allgemeines
    XI 7020 : Umwelt (Infektionen, Strahlen, Licht, Elektrizität, Klimatische Faktoren, Ernährung, Vergiftung, Epidemiologie), Nebenwirkungen
  • Keywords: Krebs > Arzneimittelresistenz > Pharmakotherapie
  • Origination:
  • Footnote: Includes bibliographical references and index
  • Description: Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.