Retinoblastoma

Media type: E-Book

Title: Retinoblastoma

Contains: Anchor 1; Anchor 2; Biology of Retinoblastoma; Landmark Discoveries in Cancer Genetics; The Retinoblastoma Paradox; Secondary Genetic Lesions in Retinoblastoma; Preclinical Models of Retinoblastoma; Improving Retinoblastoma Treatment with Preclinical Studies; Cell of Origin for Retinoblastoma; Conclusions; References; Epidemiology; Introduction; Incidence; Population Differences in Incidence; Variation Within Countries: Subpopulations with Higher Incidence; Gender Differences; Biologic Underpinnings of Epidemiologic Studies on Retinoblastoma; Potential Hypotheses; Parental Occupations
Parental AgeIn Vitro Fertilization (IVF); UV Exposure; Nonoccupational Parental Exposures; Diet; Viral Agents; Diagnostic Interval; Screening and Media Campaigns; Summary; References; Clinical Features, Diagnosis, Pathology; Introduction; Initial Presentation; Clinical History; Initial Examination; Differential Diagnosis; Examination Under Anesthesia; Fine Needle Aspiration Biopsy; Grouping and Staging of Retinoblastoma; Pathology; Histologic Features; Extraocular Extension, Metastasis, and Prognostic Factors; Metastasis; Prognostic Factors for Metastasis
Trilateral Retinoblastoma and Other TumorsProcessing of Eyes with Retinoblastoma for Histopathologic Examination; References; Genetics of Retinoblastoma and Genetic Counseling; Introduction; Molecular Genetic Progression of Retinoblastoma; The RB1 Gene, Protein, and Function; Cell of Origin; Transient Arrest: Senescence Halts Retinoma; Post-RB1 Progressive Events; Genomic Gain of 1q: KIF14; Genomic Gain of 6p: DEK and E2F3; Genomic Gain of 2p: NMYC; Genomic Loss of 16q: CDH11; Deregulation of Apoptosis: Loss of Expression of p75NTR; Murine Models of Retinoblastoma; RB1 Knockout Mouse Models
Viral Oncoprotein-induced Murine RetinoblastomaConditional RB1 Knockout Murine Retinoblastoma Models; Limitations of Mouse Models; Summary: A Model of Retinoblastoma Development; Genetic Counseling; Heritability of Retinoblastoma; Role of Environmental Factors; Molecular Genetic Testing; RB1 Test Strategies; Sporadic Bilateral or Familial Retinoblastoma; Sporadic Unilateral Retinoblastoma; Prenatal Testing; RB1 Mutation Identification; Missense Mutations; Frameshift and Nonsense Mutations; Aberrant Splicing; Epigenetic Mutations; Translocations and Gross Deletions
Penetrance of RetinoblastomaMosaicism; Parent of Origin Effect; Conclusions and Significance; References; Radiation Therapy in the Management of Retinoblastoma; Introduction; Treatment Methods; Extraocular and High-Risk Retinoblastoma; Secondary Malignant Tumors; Nonmalignant Side Effects from Radiation Therapy; Controversies in the Management of Retinoblastoma; Recommendations; References; Chemotherapy in the Management of Retinoblastoma; Introduction; Ocular Pharmacokinetics; Ocular Drug Transporters; Chemotherapy in the Treatment of Intraocular Retinoblastoma; Unilateral Retinoblastoma
Bilateral Retinoblastoma

Contributor: Rodriguez-Galindo, Carlos [Author]; Wilson, Matthew W. [Other]

imprint: Boston, MA: Springer Science+Business Media, LLC, 2010

Extent: Online-Ressource (XII, 158p. 59 illus. in color, digital)

Language: English

DOI: 10.1007/978-0-387-89072-2

ISBN: 9780387890722

Identifier:

RVK notation: XH 9074 : Im Kindesalter (bis zu 14 Jahren)

Keywords: Retinoblastom > Kind

Origination:

Footnote: Includes bibliographical references and index

Description: Retinoblastoma is the most common cancer of the eye in children. Although it is a rare neoplasm, there are many features that make this malignancy unique. Nationally, the incidence is approximately 4 million children per year. 90 per cent of these cases occur in children under 5 and more than 90 per cent will be cured. The resulting effects of the treatment can be blindness, quality of life after survival, and/or reduced life span. However in the last few years, significant advances have been made, including the development of the first mouse models (2004)

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