Skin Cancer after Organ Transplantation

Media type: E-Book

Title: Skin Cancer after Organ Transplantation

Contains: Introduction - Historical Perspective; Skin Cancer After Transplantation: Where Did We Come From, Where Do We Go?; De Novo Post-Transplantation Malignancies: Incidence and Risk Factors; Immunosuppression; Skin Immune System; Post-Transplant Skin Cancer: The Influence of Organ and Pre-Transplant Disease; The Epidemiology of Transplant-Associated Keratinocyte Cancers in Different Geographical Regions; Etiological Factors in Cutaneous Carcinogenesis - An Introduction; Photocarcinogenesis - DNA Damage and Gene Mutations; Ultraviolet-Induced Immunosuppression: Implications for Photocarcinogenesis
Carcinogenic Mechanisms Related to Immunosuppressive TherapyOncogenic Viruses; Epidemiology of Cutaneous Human Papillomavirus Infections; Interaction Between Ultraviolet Radiation and Human Papillomavirus; Human Herpesvirus 8; Molecular Events in Skin Cancer; Molecular Pathogenesis of Basal Cell Carcinoma; Molecular Pathogenesis of Squamous Cell Carcinoma; New Trends in the Susceptibility to Melanoma; Actinic Keratoses; Squamous Cell Carcinoma; Basal Cell Carcinoma; External Anogenital Premalignant and Malignant Disease; Kaposi's Sarcoma; Malignant Melanoma; Rare Skin Cancers
Merkel Cell CarcinomaCutaneous Lymphomas; Appendageal Malignancies; The Role of the Transplant Physician in the Management of Skin Cancers After Organ Transplantation; Pretransplantation Dermatologic Screening and Prophylaxis; Aftercare - A Multi-disciplinary Approach; Evaluation of Patient Education; Sunscreens and Sun Protection; Surgical Intervention for Skin Cancer in Organ Transplant Recipients; Topical Treatment of Field Cancerization; Destructive Management of Skin Cancers in Organ Transplant Recipients; Systemic Chemoprevention
Management of Metastatic Skin Cancers in Organ Transplant Recipients
Introduction: historical perspective / Georgios Katsanos and Vincent DonckierSkin cancer after transplantation: where did we come from, where do we go? / Robin Marks -- Part I. Transplant medicine -- De novo post-transplantation malignancies: incidence and risk factors / Jacques Dantal -- Immunosuppression / Edward K. Geissler -- Skin immune system / Jan D. Bos and Rosalie M. Luiten -- Part II. Post-transplant cancer -- Post-transplant skin cancer: the influence of organ and pre-transplant disease / Sylvie Euvrard and Alain Claudy -- The epidemiology of transplant-associated keratinocyte cancers in different geographical regions / Charlotte M. Proby ... [et al.] -- Etiological factors in cutaneous carcinogenesis: an introduction / Hermina C. Wisgerhof and Jan N. Bouwes Bavinck -- Photocarcinogenesis: DNA damage and gene mutations / Frank R. de Gruijl and Pieter Voskamp -- Ultraviolet-induced immunosuppression: implications for photocarcinogenesis / Stefan Beissert and Thomas Schwarz -- Carcinogenic mechanisms related to immunosuppressive therapy / Conal M. Perrett, Catherine A. Harwood, Jane M. McGregor, and Peter Karran -- Oncogenic viruses / Herbert Pfister -- Epidemiology of cutaneous human papillomavirus infections / Elsemieke I. Plasmeijer ... [et al.] -- Interaction between ultraviolet radiation and human papillomavirus / Alan Storey and Mark Simmonds -- Human herpesvirus 8 / Celeste Lebbé and Camille Francès -- Molecular events in skin cancer / Thomas Meyer -- Molecular pathogenesis of basal cell carcinoma / T. Meyer -- Molecular pathogenesis of squamous cell carcinoma / Ingo Nindl and Frank Rösl -- New trends in the susceptibility of melanoma / Nadem Soufir, Bernard Grandchamp, and Nicole Basset-Seguin -- Part III. Specific skin cancers -- Actinic keratoses / Eggert Stockfleth -- Squamous cell carcinoma / Anna Belloni Fortina, Stefan Piaserico, Mauro Alaibac, and Andrea Peserico -- Basal cell carcinoma / Carlos Ferrándiz, María J. Fuente, Lara Ferrándiz, and José M. Carrascosa -- External anogenital premalignant and malignant disease / Karen L. Gibbon, Arucha L. Ekeowa-Anderson, and Irene M. Leigh -- Kaposi's sarcoma / Camille Francès and Céleste Lebbé -- Malignant melanoma / Beata Imko-Walczuk, Richard Turner, and Fenella Wojnarowska -- Rare skin cancers / Jean Kanitakis -- Merkel cell carcinoma / Jean Kanitakis -- Cutaneous lymphomas / Deniz Seçkin and Günter F.L. Hobfauer -- Appendageal malignancies / Catherine A. Harwood, Charlotte M. Proby, and Rino Cerio -- Part IV. Prophylaxis and therapy -- The role of the transplant physician in the management of skin cancers after organ transplantation / Emmanuel Morelon, Emmanuel Mahe, and Jean-Louis Touraine -- Pretransplantation dermatologic screening and prophylaxis / Clark C. Otley -- Aftercare: a multi-disciplinary approach / Alexandra Geusau and Erich Pohanka -- Evaluation of patent education / Luigi Naldi and Fabrizia Sassi -- Sunscreens and sun protection / Jason Fallon and Gillian M. Murphy -- Surgical intervention for skin cancer in organ transplant recipients / Henry W. Randle -- Topical treatment of field cancerization / Claas Ulrich -- Destructive management of skin cancers in organ transplant recipients / Jonathan Ng, Alvin Chong, and Peter Foley -- Systemic chemoprevention / Stephen Shumack -- Management of metastatic skin cancers in organ transplant recipients / Steve Nicholson.

Contributor: Rosen, Steven T. [Author]; Stockfleth, Eggert [Other]; Ulrich, Claas [Other]

imprint: [New York, NY]: Springer, 2009
[Heidelberg]: Springer, 2009

Issue: 1

Extent: Online-Ressource (digital)

Language: English

DOI: 10.1007/978-0-387-78574-5

ISBN: 9780387785745

Identifier:

RVK notation: XH 9150 : Allgemeines
YI 6520 : Umwelt (Infektionen, Strahlen, Licht, Elektrizität, Klimatische Faktoren, Ernährung, Vergiftung, Epidemiologie), Nebenwirkungen

Keywords: Transplantation > Hautkrebs

Origination:

Footnote: Includes bibliographical references and index

Description: Organ transplantation has been performed for almost 40 years with steadily increasing success regarding long-time survival of the graft, as well as quality of life for the patient. However, graft tolerance only can be achieved via induction and maintenance of an impaired immunological surveillance. An increase of skin cancers as a consequence of the lowered cellular immunoresponse seems to parallel the overall increased long-time survival rate of organ transplant recipients. Against the background of chronic immunosuppression known risk factors like the amount of sun exposure prior and post transplantation, oncogenic viruses as well as the genetic background, and place of residence (latitude) are strongly related with the increased skin cancer incidence. The increasing incidence of non-melanoma skin cancer, paralleling a prolonged survival of patients after organ transplantation, represents a significant reason for morbidity and long-term morbidity in organ transplant recipients worldwide. The incidence of non-melanoma skin cancer in liver-, kidney- and heart transplant recipients varies from 1.5 to 22 %, 2 to 24 % and 6 to 34 % after < 5 years post transplant. Ultraviolet radiation as well as immunosuppressive therapy are crucial risk-factors regarding the induction and progression of skin cancer. Ultraviolet radiation is related to the induction of DNA damage, as well as interference with Langerhans cell antigen presentation and a Th1 – Th2 shift induced via a release of IL-10. Whereas the overall duration of immunosuppression and the cumulative dosage applied are relevant parameters in the evaluation of an increased tumor risk, individual differences between specific immunosuppressive agents remain unclear. The workup of genetic as well as other unclear phenomenon like the reverse BCC/SCC ratio might shed some further light into the genesis and immunology of the non-melanoma skin cancer in general.

Skin Cancer after Organ Transplantation - [1]

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