Description:
This book is a rich source of information on skin disorders due to toxicants in the environment. State of the art knowledge is summarized concerning the molecular basis of skin damage caused by well-appreciated environmental noxae. The book also provides a uniquely comprehensive overview of the detrimental dermatological effects of exposure to air pollution and global climate change. A special focus is contact allergy, which, beyond representing a major problem in dermatotoxicology, serves as a prime example for the development of toxicological approaches to risk assessment. A further chapter is devoted to contact urticaria, a condition that can progress to life-threatening anaphylactic reactions. The novel information offered in this book will enable the reader to go beyond the traditional thinking of dermatotoxicology and achieve a modern appreciation of the highly complex interplay between skin and environment
General Aspects of Dermatotoxicology: Skin as a metabolizing organ -- Skin toxicology in the 21st century: Modern Risk Assessment Strategies -- Risk assessment for contact allergens. Environmental threats to skin: UV and skin: photoaging -- UV and skin: photocarcinogenesis -- Actinic skin damage beyond UV -- Tobacco smoke and skin -- Ozone and skin: Italy -- PM and skin -- Contact allergy -- Contact urticaria / Anaphylaxis -- Arsen and skin -- PAHs and skin -- Global climate change and skin diseases -- Global climate change, pollen and allergy