> Details

Pfennig, Andrea [Other]; Reif, Andreas [Other]; Rottmann-Wolf, Maren [Other]; Schmitt, Natalie M. [Other]; Stamm, Thomas [Other]; Juckel, Georg [Other]; Bauer, Michael [Other]; Leopold, Karolina [Other]; Bechdolf, Andreas [Other]; Correll, Christoph U. [Other]; Holtmann, Martin [Other]; Lambert, Martin [Other]; Marx, Carolin [Other]; Meyer, Thomas D. [Other]; Pfeiffer, Steffi [Other]

Early specific cognitive-behavioural psychotherapy in subjects at high risk for bipolar disorders: study protocol for a randomised controlled trial

Reference
management

Bookmarks

Remove from
bookmarks

Share this on Whatsapp

Close

Bookmarks



You can manage bookmarks using lists, please log in to your user account for this.
  • Media type: E-Book; Special Print
  • Title: Early specific cognitive-behavioural psychotherapy in subjects at high risk for bipolar disorders: study protocol for a randomised controlled trial
  • Contributor: Pfennig, Andrea [Other]; Reif, Andreas [Other]; Rottmann-Wolf, Maren [Other]; Schmitt, Natalie M. [Other]; Stamm, Thomas [Other]; Juckel, Georg [Other]; Bauer, Michael [Other]; Leopold, Karolina [Other]; Bechdolf, Andreas [Other]; Correll, Christoph U. [Other]; Holtmann, Martin [Other]; Lambert, Martin [Other]; Marx, Carolin [Other]; Meyer, Thomas D. [Other]; Pfeiffer, Steffi [Other]
  • Published: London: BioMed Central, 2014
    Online-Ausg., Dresden: Saechsische Landesbibliothek - Staats- und Universitaetsbibliothek Dresden
  • Language: English
  • Identifier:
  • RVK notation: XA 10000 : Medizinische Zeitschriften
  • Type of reproduction: Online-Ausg.
  • Place of reproduction: Dresden: Saechsische Landesbibliothek - Staats- und Universitaetsbibliothek Dresden
  • Origination:
  • Footnote: Aus: Trials, 2014, Volume 15, Issue 161, ISSN: 1745-6215. - Elektron. Sonderdr.: Dresden : SLUB, 2014
  • Description: Background: Bipolar disorders (BD) are among the most severe mental disorders with first clinical signs and symptoms frequently appearing in adolescence and early adulthood. The long latency in clinical diagnosis (and subsequent adequate treatment) adversely affects the course of disease, effectiveness of interventions and health-related quality of life, and increases the economic burden of BD. Despite uncertainties about risk constellations and symptomatology in the early stages of potentially developing BD, many adolescents and young adults seek help, and most of them suffer substantially from symptoms already leading to impairments in psychosocial functioning in school, training, at work and in their social relationships. We aimed to identify subjects at risk of developing BD and investigate the efficacy and safety of early specific cognitive-behavioural psychotherapy (CBT) in this subpopulation. Methods/Design: EarlyCBT is a randomised controlled multi-centre clinical trial to evaluate the efficacy and safety of early specific CBT, including stress management and problem solving strategies, with elements of mindfulness-based therapy (MBT) versus unstructured group meetings for 14 weeks each and follow-up until week 78. Participants are recruited at seven university hospitals throughout Germany, which provide in-and outpatient care (including early recognition centres) for psychiatric patients. Subjects at high risk must be 15 to 30 years old and meet the combination of specified affective symptomatology, reduction of psychosocial functioning, and family history for (schizo) affective disorders. Primary efficacy endpoints are differences in psychosocial functioning and defined affective symptomatology at 14 weeks between groups. Secondary endpoints include the above mentioned endpoints at 7, 24, 52 and 78 weeks and the change within groups compared to baseline; perception of, reaction to and coping with stress; and conversion to full BD. Discussion: To our knowledge, this is the first study to evaluate early specific CBT in subjects at high risk for BD. Structured diagnostic interviews are used to map the risk status and development of disease. With our study, the level of evidence for the treatment of those young patients will be significantly raised.
  • Information of inventory: Elektronischer Volltext - Zugang über WWW
  • Access State: Open Access
  • Rights information: In Copyright