University thesis:
Dissertation, Georg-August-Universität Göttingen, 2019
Footnote:
Description:
Myelin is a multi-layered membrane wrapped around axons. It allows fast nerve conduction and provides the axon with trophic support. In the central nervous sys- tem (CNS), oligodendrocytes form multiple myelin sheaths. Thus, a single oligo- dendrocyte has to coordinate the generation of numerous myelin segments on dif- ferent axons. A cellular model of myelin sheath generation has been provided, but the molecular mechanisms of multiple aspects of myelination such as initiation, lat- eral growth and termination are still elusive. During myelination, the inner leaflet is actively growing by a...