University thesis:
Dissertation, Georg-August-Universität Göttingen, 2019
Footnote:
Description:
Clathrin adaptor protein complexes 1 and 2 (AP1 and AP2) have essential functions in synaptic vesicle (SV) recycling. In all cell types and tissues, AP1 mediates TGN/endosome protein sorting via clathrin-coated-vesicles (CCV), whereas AP2 transports proteins by clathrin-mediated endocytosis (CME). Both AP complexes are heterotetrameric, made of four adaptins. Neurons express the ubiquitous AP1/σ1A complex and in addition, the tissue-specific AP1/σ1B complex. In our lab, we have generated σ1B-/- mice. The deficiency of σ1B adaptin leads to severe learning, memory and motor coordination defic...