• Media type: E-Book; Thesis
  • Title: Chemical and biological investigations of cytotoxic metal complexes
  • Contributor: Hildebrandt, Jana [VerfasserIn]; Weigand, Wolfgang [AkademischeR BetreuerIn]; Dürst, Matthias [AkademischeR BetreuerIn]; Metzler-Nolte, Nils [AkademischeR BetreuerIn]
  • Corporation: Friedrich-Schiller-Universität Jena
  • imprint: Jena, 2019
  • Extent: 1 Online-Ressource (361 Seiten); Illustrationen, Diagramme
  • Language: English; German
  • DOI: 10.22032/dbt.38671
  • Identifier:
  • Keywords: Metallkomplexe > Cytostatikum > Eierstockkrebs
  • Origination:
  • University thesis: Dissertation, Friedrich-Schiller-Universität Jena, 2019
  • Footnote: Kumulative Dissertation, enthält Zeitschriftenaufsätze
    Tag der Verteidigung: 29.05.2019
    Zusammenfassungen in deutscher und englischer Sprache
  • Description: In summary, this works presents new metal(II) complexes with promising cytotoxic activity against Cisplatin resistant cell lines by following a different mechanism of action and showing higher cancer selectivity in vitro. To conclude, it was shown that asparagusic acid derivatives can coordinate to platinum(II) and show some interesting results on Cisplatin resistant ovarian cancer cell lines by following a different mode of action.
  • Access State: Open Access