> Details
Hasan, Mazahir
[Author];
Althammer, Ferdinand
[Author];
Silva da Gouveia, Miriam
[Author];
Goyon, Stephanie
[Author];
Eliava, Marina
[Author];
Lefevre, Arthur
[Author];
Kerspern, Damien
[Author];
Schimmer, Jonas
[Author];
Raftogianni, Androniki
[Author];
Wahis, Jerome
[Author];
Knobloch-Bollmann, Hanna Sophie
[Author];
Tang, Yan
[Author];
Liu, Xinying
[Author];
Jain, Apar
[Author];
Chavant, Virginie
[Author];
Goumon, Yannick
[Author];
Weislogel, Jan-Marek
[Author];
Hurlemann, René
[Author];
Herpertz, Sabine
[Author];
Pitzer, Claudia
[Author];
Darbon, Pascal
[Author];
Dogbevia, Godwin K.
[Author];
Bertocchi, Ilaria
[Author];
Larkum, Matthew E.
[Author];
[...]
A fear memory engram and its plasticity in the hypothalamic oxytocin system
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- Media type: E-Article
- Title: A fear memory engram and its plasticity in the hypothalamic oxytocin system
- Contributor: Hasan, Mazahir [VerfasserIn]; Althammer, Ferdinand [VerfasserIn]; Silva da Gouveia, Miriam [VerfasserIn]; Goyon, Stephanie [VerfasserIn]; Eliava, Marina [VerfasserIn]; Lefevre, Arthur [VerfasserIn]; Kerspern, Damien [VerfasserIn]; Schimmer, Jonas [VerfasserIn]; Raftogianni, Androniki [VerfasserIn]; Wahis, Jerome [VerfasserIn]; Knobloch-Bollmann, Hanna Sophie [VerfasserIn]; Tang, Yan [VerfasserIn]; Liu, Xinying [VerfasserIn]; Jain, Apar [VerfasserIn]; Chavant, Virginie [VerfasserIn]; Goumon, Yannick [VerfasserIn]; Weislogel, Jan-Marek [VerfasserIn]; Hurlemann, René [VerfasserIn]; Herpertz, Sabine [VerfasserIn]; Pitzer, Claudia [VerfasserIn]; Darbon, Pascal [VerfasserIn]; Dogbevia, Godwin K. [VerfasserIn]; Bertocchi, Ilaria [VerfasserIn]; Larkum, Matthew E. [VerfasserIn]; Sprengel, Rolf [VerfasserIn]; Bading, Hilmar [VerfasserIn]; Charlet, Alexandre [VerfasserIn]; Grinevich, Valéry [VerfasserIn]
-
imprint:
16 May 2019
- Published in: Neuron ; 103(2019), 1, Seite 133-146
- Language: English
- DOI: 10.1016/j.neuron.2019.04.029
- ISSN: 1097-4199
- Identifier:
- Origination:
- Footnote:
- Description: Oxytocin (OT) release by axonal terminals onto the central nucleus of the amygdala exerts anxiolysis. To investigate which subpopulation of OT neurons contributes to this effect, we developed a novel method: virus-delivered genetic activity-induced tagging of cell ensembles (vGATE). With the vGATE method, we identified and permanently tagged a small subpopulation of OT cells, which, by optogenetic stimulation, strongly attenuated contextual fear-induced freezing, and pharmacogenetic silencing of tagged OT neurons impaired context-specific fear extinction, demonstrating that the tagged OT neurons are sufficient and necessary, respectively, to control contextual fear. Intriguingly, OT cell terminals of fear-experienced rats displayed enhanced glutamate release in the amygdala. Furthermore, rats exposed to another round of fear conditioning displayed 5-fold more activated magnocellular OT neurons in a novel environment than a familiar one, possibly for a generalized fear response. Thus, our results provide first evidence that hypothalamic OT neurons represent a fear memory engram.
- Access State: Open Access