University thesis:
Dissertation, Georg-August-Universität Göttingen, 2019
Footnote:
Description:
Adaptation to changing environmental conditions is crucial for any organism to thrive in nature. Bacteria like the Gram-positive model organism Bacillus subtilis have evolved so-called second messengers to facilitate signal transduction processes. An important and unique second messenger is cyclic di-AMP (c-di-AMP) which has been discovered ten years ago. This small molecule has attracted much attention as it is essential for many bacteria that produce it but also can become toxic upon accumulation. Accordingly, it has been coined “essential poison”. In B. subtilis an essential function of ...