Footnote:
Includes bibliographical references and index
Description:
An emerging field at the interface of biology and engineering, mechanobiology explores the mechanisms by which cells sense and respond to mechanical signals and holds great promise in one day unravelling the mysteries of cellular and extracellular matrix mechanics to cure a broad range of diseases. Mechanobiology: Exploitation for Medical Benefit presents a comprehensive overview of principles of mechanobiology, highlighting the extent to which biological tissues are exposed to the mechanical environment, demonstrating the importance of the mechanical environment in living systems, and critically reviewing the latest experimental procedures in this emerging field. Featuring contributions from several top experts in the field, chapters begin with an introduction to fundamental mechanobiological principles; and then proceed to explore the relationship of this extensive force in nature to tissues of musculoskeletal systems, heart and lung vasculature, the kidney glomerulus, and cutaneous tissues. Examples of some current experimental models are presented conveying relevant aspects of mechanobiology, highlighting emerging trends and promising avenues of research in the development of innovative therapies. Timely and important, Mechanobiology: Exploitation for Medical Benefit offers illuminating insights into an emerging field that has the potential to revolutionise our comprehension of appropriate cell biology and the future of biomedical research
Extracellular Matrix Structure and Stem Cell Mechanosensing / Nicholas D Evans, Camelia G Tusan -- Molecular Pathways of Mechanotransduction / Hamish T J Gilbert, Joe Swift -- Sugar-Coating the Cell / Stefania Marcotti, Gwendolen C Reilly -- The Role of the Primary Cilium in Cellular Mechanotransduction / Kian F Eichholz, David A Hoey -- Mechanosensory and Chemosensory Primary Cilia in Ciliopathy and Ciliotherapy / Surya M Nauli, Rinzhin T Sherpa, Caretta J Reese, Andromeda M Nauli -- Mechanobiology of Embryonic Skeletal Development / Andrea S Pollard, Andrew A Pitsillides -- Modulating Skeletal Responses to Mechanical Loading by Targeting Estrogen Receptor Signaling / Gabriel L Galea, Lee B Meakin -- Mechanical Responsiveness of Distinct Skeletal Elements / Simon C F Rawlinson -- Pulmonary Vascular Mechanics in Pulmonary Hypertension / Zhijie Wang, Lian Tian, Naomi C Chesler -- Mechanobiology and the Kidney Glomerulus / Franziska Lausecker, Christoph Ballestrem, Rachel Lennon -- Dynamic Remodeling of the Heart and Blood Vessels / Ken Takahashi, Hulin Piao, Keiji Naruse -- Aortic Valve Mechanobiology / K Jane Grande-Allen, Daniel Puperi, Prashanth Ravishankar, Kartik Balachandran -- Testing the Perimenopause Ageprint using Skin Visoelasticity under Progressive Suction / Gérald E Piérard, Claudine Piérard-Franchimont, Ulysse Gaspard, Philippe Humbert, Sébastien L Piérard -- Mechanobiology and Mechanotherapy for Skin Disorders / Chao-Kai Hsu, Rei Ogawa -- Mechanobiology and Mechanotherapy for Cutaneous Wound-Healing / Chenyu Huang, Yanan Du, Rei Ogawa -- Mechanobiology and Mechanotherapy for Cutaneous Scarring / Rei Ogawa, Chenyu Huang -- Mechanobiology and Mechanotherapy for the Nail / Hitomi Sano, Rei Ogawa -- Bioreactors / James R Henstock, Alicia J El Haj -- Cell Sensing of the Physical Properties of the Microenvironment at Multiple Scales / Julien E Gautrot -- Predictive Modeling in Musculoskeletal Mechanobiology / Hanifeh Khayyeri, Hanna Isaksson, Patrick J Prendergast -- Porous Bone Graft Substitutes / Charlie Campion, Karin A Hing -- Exploitation of Mechanobiology for Cardiovascular Therapy / Winston Elliott, Amir Keshmiri, Wei Tan.