> Details

Maus, Andreas [Author] ; Streckfuß-Bömeke, Katrin [Degree supervisor]; Meyer, Thomas [Degree supervisor]; Shah, Ajay [Degree supervisor]; Walter, Lutz [Degree supervisor]; Zelarayán, Laura [Degree supervisor]; Thoms, Sven [Degree supervisor]; Behr, Rüdiger [Degree supervisor]

Human induced pluripotent stem cell models used in the study of doxorubicin-induced cardiomyopathy

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  • Media type: E-Book; Thesis
  • Title: Human induced pluripotent stem cell models used in the study of doxorubicin-induced cardiomyopathy
  • Contributor: Maus, Andreas [Author]; Streckfuß-Bömeke, Katrin, [Degree supervisor]; Meyer, Thomas [Degree supervisor]; Shah, Ajay [Degree supervisor]; Walter, Lutz [Degree supervisor]; Zelarayán, Laura [Degree supervisor]; Thoms, Sven [Degree supervisor]; Behr, Rüdiger [Degree supervisor]
  • Published: Göttingen, 2020
  • Extent: 1 Online-Ressource; Illustrationen, Diagramme
  • Language: English
  • Identifier:
  • Keywords: Hochschulschrift
  • Origination:
  • University thesis: Dissertation, Georg-August-Universität Göttingen, 2020
  • Footnote:
  • Description: Doxorubicin (DOX) has been used for decades to treat hematopoietic and solid tumors, although, in a subset of cancer survivors, it causes cardiotoxicity decades after treatment. The mechanisms of anthracycline-induced cardiotoxicity (ACT) are still incompletely understood. Induced pluripotent stem cells (iPSCs)-derived cardiomyocytes have become a valuable tool to study hereditary and structural cardiac conditions in vitro. A former study from our group showed that iPSC-derived cardiomyocytes (iPSC-CMs) from lymphoma patients with ACT were continuously more sensitive to DOX toxicity, demons...
  • Access State: Open Access