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Media type:
E-Book;
Thesis
Title:
Tumorwachstum und Expression der Matrixmetalloproteinase-9 in einem orthotopen Pankreaskarzinom-Mausmodell unter der Einwirkung von chronischem Stress
Pancreatic carcinomas are among the most aggressive tumor entities, metastasize early and have a very poor prognosis. Chronic stress could even worsen the bad prognosis. In this work we investigated in vivo in a murine, syngenic and immunocompetent pancreatic carcinoma model using magnetic resonance imaging whether chronic stress had an effect on tumor progression of orthotopically implanted pancreatic carcinoma cells in C57BL/6 mice. Stress quantification was clearly validated by a stress score and by measuring corticosterone levels from the serum of the mice.The expression of matrix metalloproteinases-9 in the tumor stroma was investigated immunohistochemically. The results showed a stress-induced faster tumor growth with consecutively worse survival prognosis. A non-selective β receptor blockade with propranolol significantly reduced the negative effects of stress and prolonged the survival of the tumor carrying animals under stress conditions. The immunohistochemical results showed an increased MMP-9 expression in the tumor stroma under stress conditions.