University thesis:
Dissertation, Georg-August-Universität Göttingen, 2020
Footnote:
Description:
The organic cation transporter 1 (OCT1) is primarily located in the sinusoidal membranes of hepatocytes and mediates phase 0 biotransformation of xenobiotics, including weak basic and cationic drugs. Variations in SLC22A1, the gene encoding OCT1, are common throughout the Caucasian population. Close to 9% of Caucasians are homozygotic for OCT1 alleles that encode insufficient transporters, resulting in a partial or complete loss of OCT1 transport activity in affected individuals. Clinical studies have demonstrated that diminished OCT1 transport activity leads to elevated plasma levels of op...