Einfluss der Serumharnsäure auf die Nierenfunktion (eGFR, ACR) in der Allgemeinbevölkerung über einen Beobachtungszeitraum von 15 Jahren (Study of Health in Pomerania)
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Media type:
E-Book;
Thesis
Title:
Einfluss der Serumharnsäure auf die Nierenfunktion (eGFR, ACR) in der Allgemeinbevölkerung über einen Beobachtungszeitraum von 15 Jahren (Study of Health in Pomerania)
Approximately 10 Million people are affected by chronic kidney disease in Germany. Its appearance is associated with elevated cardiovascular mortality and morbidity. For a long time, high serum uric acid levels have been considered rather the result than the cause of developing chronic kidney disease. The aim of this study was to examine the association between elevated serum uric acid levels (as a continuous variable) and the decline in kidney function (eGFR, ACR) in a general population. We analyzed data from 4042 healthy individuals participating in the “Study of Health in Pomerania” (SHIP – a population based longitudinal observational study of the general population in western Pomerania since 1996) to determine the association between elevated serum uric acid levels and the development of chronic kidney disease. By using a multivariate regression model, we estimated the decline in eGFR and the rise in ACR over a period of 15 years (SHIP-0 to SHIP-3). Data of healthy participants with different levels of serum uric acid or with phenotype hyperuricemia were implemented in our regression model and used to estimate eGFR and ACR. Phenotype hyperuricemia was present if gout or elevated serum uric acid levels or intake of gout specific medication were declared or study lab results revealed elevated serum uric acid levels. In women uric acid levels above > 357 μmol/l or in men levels above > 428 μmol/l were considered to be elevated. The result of our multivariate model ...