University thesis:
Dissertation, Georg-August-Universität Göttingen, 2020
Footnote:
Description:
One-carbon metabolism (1CM) plays a central role in cell proliferation and an elevated activity is accounted for the progression of several cancer types. Increased 1CM is a known risk factor for lung cancer and the anti-folate pemetrexed is one of the current standard first-line therapies for non-operable pulmonary adenocarcinoma. The underlining mechanism, the expression and the function of 1CM enzymes in the development and progression of lung cancer remain to be explored. Here, we investigated the 1CM key enzymes MTHFD2, PGDH3, SHMT2, MTHFD1 and TYMS in 323 human lung cancer tissues samp...