University thesis:
Dissertation, Georg-August-Universität Göttingen, 2020
Footnote:
Description:
Cell-penetrating peptides (CPPs) are often rich in arginine. They are able to cross cell membranes and carry other molecules into cells without being cytotoxic. The mechanisms by which they accomplish this are still controversial, although endocytotic pathways or spontaneous entry mechanisms have both been proposed. This work takes a bottom-up approach to the role of arginine in CPPs, by comparing an arginine side chain mimic with arginine oligopeptides of different length, with respect to their influence on membrane model systems of various lipid compositions. Simulations as well as breakt...