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Reynel, María [Author]; Villegas, Yván [Author]; Kiene, Helmut [Author]; Werthmann, Paul Georg Heinrich [Author]; Kienle, Gunver Sophia [Author]

Intralesional and subcutaneous application of Viscum album L. (European mistletoe) extract in cervical carcinoma in situ: a CARE compliant case report

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  • Media type: E-Book; Special Print
  • Title: Intralesional and subcutaneous application of Viscum album L. (European mistletoe) extract in cervical carcinoma in situ: a CARE compliant case report
  • Contributor: Reynel, María [Author]; Villegas, Yván [Author]; Kiene, Helmut [Author]; Werthmann, Paul Georg Heinrich [Author]; Kienle, Gunver Sophia [Author]
  • Published: Baltimore, Md.: Ovid Technologies (Wolters Kluwer Health), 2018
  • Published in: Medicine ; 97, 48 (2018), e13420
  • Extent: 1 Online-Ressource (6 Seiten); Illustrationen, Diagramme
  • Language: English
  • DOI: 10.1097/md.0000000000013420
  • Identifier:
  • Origination:
  • Footnote:
  • Description: Abstract: Rationale: <br>Carcinoma in situ (CIS) of the uterine cervix is a premalignant condition of squamous epithelium. The standard treatments are excision and ablation procedures; for women with positive margins, hysterectomy is recommended.<br><br>Patient concerns: <br>A 47-year-old Peruvian woman with recurrent candidal vaginitis had been diagnosed with colpocervicitis and squamous metaplasia 8 years ago, which were not treated.<br><br>Diagnoses: <br>The patient was diagnosed with CIS after cervical conization procedure. She refused radical hysterectomy and opted for integrative medicine treatment.<br><br>Interventions: <br>She was treated with intralesional and subcutaneous Viscum album L. extract (VAE) injections. VAE is a widely used herbal cancer treatment with cytotoxic, apoptogenic, and immunological effects, but it has not been investigated in cervical CIS.<br><br>Outcomes: <br>Ending month 5 of treatment, complete remission of cervical CIS was observed. The patient is still in remission after 30 months (until publication).<br><br>Lessons: <br>This is the first report on complete remission of cervical CIS after intralesional and subcutaneous injection with VAE. Prospective studies should evaluate to what degree the treatment effect is reproducible
  • Access State: Open Access