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Shen, Xueyi [Author]; Howard, David M. [Author]; Adams, Mark J. [Author]; Hill, W. David [Author]; Clarke, Toni-Kim [Author]; Deary, Ian J. [Author]; Whalley, Heather C. [Author]; McIntosh, Andrew M. [Author]; Domschke, Katharina [Author]

A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

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  • Media type: E-Book; Special Print
  • Title: A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank
  • Contributor: Shen, Xueyi [VerfasserIn]; Howard, David M. [VerfasserIn]; Adams, Mark J. [VerfasserIn]; Hill, W. David [VerfasserIn]; Clarke, Toni-Kim [VerfasserIn]; Deary, Ian J. [VerfasserIn]; Whalley, Heather C. [VerfasserIn]; McIntosh, Andrew M. [VerfasserIn]; Domschke, Katharina [VerfasserIn]
  • imprint: London: Nature Publishing Group UK, 2020
  • Published in: Nature communications ; 11, 1 (2020), 2301
  • Extent: 1 Online-Ressource (16 Seiten); Diagramme; Supplementary information (1 ZIP-Datei: 4 PDF-Dateien, 14 .xlsx- Dateien)
  • Language: English
  • DOI: 10.1038/s41467-020-16022-0
  • ISSN: 2041-1723
  • Identifier:
  • Origination:
  • Footnote:
  • Description: Abstract: Depression is a leading cause of worldwide disability but there remains considerable uncertainty regarding its neural and behavioural associations. Here, using non-overlapping Psychiatric Genomics Consortium (PGC) datasets as a reference, we estimate polygenic risk scores for depression (depression-PRS) in a discovery (N = 10,674) and replication (N = 11,214) imaging sample from UK Biobank. We report 77 traits that are significantly associated with depression-PRS, in both discovery and replication analyses. Mendelian Randomisation analysis supports a potential causal effect of liability to depression on brain white matter microstructure (β: 0.125 to 0.868, pFDR < 0.043). Several behavioural traits are also associated with depression-PRS (β: 0.014 to 0.180, pFDR: 0.049 to 1.28 × 10−14) and we find a significant and positive interaction between depression-PRS and adverse environmental exposures on mental health outcomes. This study reveals replicable associations between depression-PRS and white matter microstructure. Our results indicate that white matter microstructure differences may be a causal consequence of liability to depression
  • Access State: Open Access