> Details

Hoff, Jessica [Author]; Karl, Berit [Author]; Gerstmeier, Jana Karin [Author]; Beekmann, Uwe Sven [Author]; Schmölz, Lisa [Author]; Börner, Friedemann [Author]; Kralisch, Dana [Author]; Bauer, Michael [Author]; Werz, Oliver [Author]; Fischer, Dagmar [Author]; Lorkowski, Stefan [Author]; Press, Adrian Tibor [Author]

Controlled Release of the α-Tocopherol-Derived Metabolite α-13′-Carboxychromanol from Bacterial Nanocellulose Wound Cover Improves Wound Healing

Reference
management

Bookmarks

Remove from
bookmarks

Share this on Whatsapp

Close

Bookmarks



You can manage bookmarks using lists, please log in to your user account for this.
  • Media type: E-Article
  • Title: Controlled Release of the α-Tocopherol-Derived Metabolite α-13′-Carboxychromanol from Bacterial Nanocellulose Wound Cover Improves Wound Healing
  • Contributor: Hoff, Jessica [VerfasserIn]; Karl, Berit [VerfasserIn]; Gerstmeier, Jana Karin [VerfasserIn]; Beekmann, Uwe Sven [VerfasserIn]; Schmölz, Lisa [VerfasserIn]; Börner, Friedemann [VerfasserIn]; Kralisch, Dana [VerfasserIn]; Bauer, Michael [VerfasserIn]; Werz, Oliver [VerfasserIn]; Fischer, Dagmar [VerfasserIn]; Lorkowski, Stefan [VerfasserIn]; Press, Adrian Tibor [VerfasserIn]
  • imprint: 28 July 2021
  • Published in: Nanomaterials ; 11(2021,8) Artikel-Nummer 1939, 16 Seiten
  • Language: English
  • DOI: 10.3390/nano11081939
  • ISSN: 2079-4991
  • Identifier:
  • Origination:
  • Footnote:
  • Description: Abstract: Inflammation is a hallmark of tissue remodeling during wound healing. The inflammatory response to wounds is tightly controlled and well-coordinated; dysregulation compromises wound healing and causes persistent inflammation. Topical application of natural anti-inflammatory products may improve wound healing, in particular under chronic pathological conditions. The long-chain metabolites of vitamin E (LCM) are bioactive molecules that mediate cellular effects via oxidative stress signaling as well as anti-inflammatory pathways. However, the effect of LCM on wound healing has not been investigated. We administered the α-tocopherol-derived LCMs α-13′-hydroxychromanol (α-13′-OH) and α-13′-carboxychromanol (α-13′-COOH) as well as the natural product garcinoic acid, a δ-tocotrienol derivative, in different pharmaceutical formulations directly to wounds using a splinted wound mouse model to investigate their effects on the wounds’ proinflammatory microenvironment and wound healing. Garcinoic acid and, in particular, α-13′-COOH accelerated wound healing and quality of the newly formed tissue. We next loaded bacterial nanocellulose (BNC), a valuable nanomaterial used as a wound dressing with high potential for drug delivery, with α-13′-COOH. The controlled release of α-13′-COOH using BNC promoted wound healing and wound closure, mainly when a diabetic condition was induced before the injury. This study highlights the potential of α-13′-COOH combined with BNC as a potential active wound dressing for the advanced therapy of skin injuries. Keywords: biocompatible nanocellulose; wound healing; drug delivery; controlled release; inflammation; tocopherols; natural products
  • Access State: Open Access