University thesis:
Dissertation, Georg-August-Universität Göttingen, 2021 (Kumulative Dissertation)
Footnote:
Kumulative Arbeit
Description:
Ykt6 is an evolutionarily conserved R-SNARE that mediates vesicle fusion events at diverse cellular compartments of secretory, endocytic and autophagy pathways. It is known to be required for the secretion of Wnts on small extracellular vesicles termed exosomes. However, the exact molecular mechanism of Ykt6 in exosomal Wnt sorting remains unclear. Employing proximity labelling, in vivo genetics and biochemical approaches, we identified that Ykt6 acts at the level of sorting endosome where it trafficks Wnts to the PM for extracellular Wnt release. Ykt6 is a unique SNARE that lacks a transme...