Brigatinib versus other second-generation ALK inhibitors as initial treatment of anaplastic lymphoma kinase positive non-small cell lung cancer with deep phenotyping: study protocol of the ABP trial

Media type: E-Article

Title: Brigatinib versus other second-generation ALK inhibitors as initial treatment of anaplastic lymphoma kinase positive non-small cell lung cancer with deep phenotyping : study protocol of the ABP trial

Contributor: Christopoulos, Petros [Author]; Bozorgmehr, Farastuk [Author]; Brückner, Lena Marie [Author]; Chung, Inn [Author]; Krisam, Johannes [Author]; Schneider, Marc [Author]; Stenzinger, Albrecht [Author]; Eickhoff, Regina [Author]; Mueller, Daniel W. [Author]; Thomas, Michael [Author]

Published: 28 June 2021

Language: English

DOI: 10.1186/s12885-021-08460-w

Identifier:

Keywords: ALK+ NSCLC ; Anaplastic lymphoma kinase ; Brigatinib ; Molecular risk ; Non-small cell lung cancer ; Resistance mutations ; Tyrosine kinase inhibitors (TKI)

Origination:

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Description: Availability of potent anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKI) has pushed the median survival of ALK+ non-smallcell lung cancer (NSCLC) patients to over five years. In particular, second-generation ALK TKI have demonstrated superiority compared to the first-generation compound crizotinib and are meanwhile standard first-line treatment. However, clinical courses of individual patients vary widely, with secondary development of drug resistance and intracranial progression remaining important problems. While these limitations highlight the need for better disease monitoring and additional therapeutic tools, molecular tumor features are increasingly recognized as crucial determinants of clinical outcome. This trial aims to optimize management of ALK+ NSCLC by analyzing the efficacy of second-generation ALK inhibitors in conjunction with deep longitudinal phenotyping across two treatment lines.

Access State: Open Access

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