University thesis:
Dissertation, Georg-August-Universität Göttingen, 2021
Footnote:
Description:
Synaptic transmission poses a major energy consuming process in the brain, but how neurons maintain a constant energy supply during extended synaptic activity and how presynaptic mitochondria contribute to the energy supply remains elusive. The mitochondria are key organelles to account for the majority of ATP newly synthesised in neuronal cells. Hence, the present study aimed at unravelling the structural adaptation of mitochondria to an increase in presynaptic energy demand. To this end, I first characterized the mitochondrial membrane architecture and how it changes in response to differ...