Adaptive ERK signalling activation in response to therapy and in silico prognostic evaluation of EGFR-MAPK in HNSCC

Media type: E-Article
Title: Adaptive ERK signalling activation in response to therapy and in silico prognostic evaluation of EGFR-MAPK in HNSCC
Contributor: Rong, Chao [Author]; Muller, Marie France [Author]; Xiang, Fang [Author]; Jensen, Alexandra [Author]; Weichert, Wilko [Author]; Major, Gerald [Author]; Plinkert, Peter K. [Author]; Heß, Jochen [Author]; Affolter, Annette [Author]
Published: 19 May 2020
Published in: British journal of cancer ; 123(2020), 2, Seite 288-297
Language: English
DOI: 10.1038/s41416-020-0892-9
Identifier:

Keywords: Head and neck cancer ; Molecular medicine ; Prognostic markers
Origination:
Footnote:
Description: Head and neck squamous cell carcinoma (HNSCC) patients frequently develop treatment resistance to cetuximab, a monoclonal antibody against EGFR, as well as radiotherapy. Here we addressed extracellular signal-regulated kinase 1/2 (ERK1/2) regulation by cetuximab or fractionated irradiation (IR) and conducted in silico prognostic evaluation of the EGFR-MAPK axis in HNSCC.
Access State: Open Access

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