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Kreutmair, Stefanie [Author]; Klingeberg, Cathrin [Author]; Poggio, Teresa [Author]; Geoffroy, Andrieux [Author]; Keller, Alexander [Author]; Miething, Cornelius [Author]; Follo, Marie [Author]; Pfeifer, Dietmar [Author]; Shoumariyeh, Khalid [Author]; Lengerke, Claudia [Author]; Gonzalez Menendez, Irene [Author]; Fend, Falko [Author]; Zeiser, Robert [Author]; Turner, Suzanne D. [Author]; Quintanilla-Martinez, Leticia [Author]; Börries, Melanie [Author]; Duyster, Justus [Author]; Illert, Anna Lena [Author]

Existence of reprogrammed lymphoma stem cells in a murine ALCL-like model

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  • Media type: E-Book; Special Print
  • Title: Existence of reprogrammed lymphoma stem cells in a murine ALCL-like model
  • Contributor: Kreutmair, Stefanie [Author]; Klingeberg, Cathrin [Author]; Poggio, Teresa [Author]; Geoffroy, Andrieux [Author]; Keller, Alexander [Author]; Miething, Cornelius [Author]; Follo, Marie [Author]; Pfeifer, Dietmar [Author]; Shoumariyeh, Khalid [Author]; Lengerke, Claudia [Author]; Gonzalez Menendez, Irene [Author]; Fend, Falko [Author]; Zeiser, Robert [Author]; Turner, Suzanne D. [Author]; Quintanilla-Martinez, Leticia [Author]; Börries, Melanie [Author]; Duyster, Justus [Author]; Illert, Anna Lena [Author]
  • Published: London: Springer Nature, 2020
  • Published in: Leukemia ; 34, 12 (2020), 3242-3255
  • Extent: 1 Online-Ressource (14 Seiten); Diagramme; Supplementary information
  • Language: English
  • DOI: 10.1038/s41375-020-0789-x
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  • Origination:
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  • Description: Abstract: While cancer stem cells are well established in certain hematologic and solid malignancies, their existence in T cell lymphoma is unclear and the origin of disease is not fully understood. To examine the existence of lymphoma stem cells, we utilized a mouse model of anaplastic large cell lymphoma. Established NPM-ALK+ lymphomas contained heterogeneous cell populations ranging from mature T cells to undifferentiated hematopoietic stem cells. Interestingly, CD4−/CD8− double negative (DN) lymphoma cells aberrantly expressed the T cell receptor α/β chain. Serial transplantation of sorted CD4/CD8 and DN lymphoma subpopulations identified lymphoma stem cells within the DN3/DN4 T cell population, whereas all other subpopulations failed to establish serial lymphomas. Moreover, transplanted lymphoma DN3/DN4 T cells were able to differentiate and gave rise to mature lymphoma T cells. Gene expression analyses unmasked stem-cell-like transcriptional regulation of the identified lymphoma stem cell population. Furthermore, these lymphoma stem cells are characterized by low CD30 expression levels, which might contribute to limited long-term therapeutic success in patients treated with anti-CD30-targeted therapies. In summary, our results highlight the existence of a lymphoma stem cell population in a NPM-ALK-driven CD30+ mouse model, thereby giving the opportunity to test innovative treatment strategies developed to eradicate the origin of disease
  • Access State: Open Access