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Morgenstern, Marcel [Author]; Stiller, Sebastian [Author]; Lübbert, Philipp [Author]; Peikert, Christian Dominik [Author]; Dannenmaier, Stefan [Author]; Drepper, Friedel [Author]; Weill, Uri [Author]; Hoess, Philipp [Author]; Feuerstein, Reinhild [Author]; Gebert, Michael [Author]; Bohnert, Maria [Author]; Laan, Martin van der [Author]; Schuldiner, Maya [Author]; Schütze, Conny [Author]; Oeljeklaus, Silke [Author]; Pfanner, Nikolaus [Author]; Wiedemann, Nils [Author]; Warscheid, Bettina [Author]

Definition of a high-confidence mitochondrial proteome at quantitative Scale

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  • Media type: E-Book; Special Print
  • Title: Definition of a high-confidence mitochondrial proteome at quantitative Scale
  • Contributor: Morgenstern, Marcel [Author]; Stiller, Sebastian [Author]; Lübbert, Philipp [Author]; Peikert, Christian Dominik [Author]; Dannenmaier, Stefan [Author]; Drepper, Friedel [Author]; Weill, Uri [Author]; Hoess, Philipp [Author]; Feuerstein, Reinhild [Author]; Gebert, Michael [Author]; Bohnert, Maria [Author]; Laan, Martin van der [Author]; Schuldiner, Maya [Author]; Schütze, Conny [Author]; Oeljeklaus, Silke [Author]; Pfanner, Nikolaus [Author]; Wiedemann, Nils [Author]; Warscheid, Bettina [Author]
  • Published: [New York, NY]: Elsevier, 2017
  • Published in: Cell reports ; 19, 13 (2017), 2836-2852
  • Extent: 1 Online-Ressource (18 Seiten); Illustrationen, Diagramme; Supplemental Information
  • Language: English
  • DOI: 10.1016/j.celrep.2017.06.014
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  • Origination:
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  • Description: Abstract: Mitochondria perform central functions in cellular bioenergetics, metabolism, and signaling, and their dysfunction has been linked to numerous diseases. The available studies cover only part of the mitochondrial proteome, and a separation of core mitochondrial proteins from associated fractions has not been achieved. We developed an integrative experimental approach to define the proteome of yeast mitochondria. We classified > 3,300 proteins of mitochondria and mitochondria-associated fractions and defined 901 high-confidence mitochondrial proteins, expanding the set of mitochondrial proteins by 82. Our analysis includes protein abundance under fermentable and nonfermentable growth, submitochondrial localization, single-protein experiments, and subcellular classification of mitochondria-associated fractions. We identified mitochondrial interactors of respiratory chain supercomplexes, ATP synthase, AAA proteases, the mitochondrial contact site and cristae organizing system (MICOS), and the coenzyme Q biosynthesis cluster, as well as mitochondrial proteins with dual cellular localization. The integrative proteome provides a high-confidence source for the characterization of physiological and pathophysiological functions of mitochondria and their integration into the cellular environment
  • Access State: Open Access