University thesis:
Dissertation, Universität Rostock, 2021 (Kumulative Dissertation)
Footnote:
Enthält Zeitschriftenartikel
GutachterInnen: Matthias Beller (Leibniz Institute for Catalysis) ; Shoubhik Das (University of Antwerp)
Description:
Herein is reported the application of non-noble metal-based catalytic systems for the homogeneous oxidation of organic substrates using air, specifically in amines and N-heterocycles. Simple 3d metal salts have been used, in combination with N-ligands, to facilitate the oxidative cleavage of C(sp3)–C(sp3) bonds. These reactions have been studied, using spectroscopic methods, to propose plausible mechanistic pathways. We believe such deconstructive strategies can enable late-stage functionalisation of pharmaceuticals and the synthesis of drug metabolites.<eng>