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Media type:
E-Book;
Thesis
Title:
Troponin-Test im Alltag
:
Beeinflussung der Gütekriterien durch Leitsymptome und Unterschiede des Outcomes von Patienten mit auffälligem Test und Patienten mit unauffälligem Test
Parallel title:
Troponin test in clinical daily practice
University thesis:
Dissertation, Georg-August-Universität Göttingen, 2022
Footnote:
Description:
Abstract Introduction Cardiac troponins are the prefered cardial biomarker in the diagnosis of acute myocardial infarction. With the new Troponin-Assays minimal troponin concentration can be detectable. This makes the interpretation of a positive test very difficult, taking to consideration the wide variety of causes of troponin release. The aim of this study is to assess the quality criteria of the troponin test in the diagnosis of acute myocardial infarction in everyday life and asses the influence of leading symptom on the quality criteria of the test. Methods This is a retrospective c...
AbstractIntroduction Cardiac troponins are the prefered cardial biomarker in the diagnosis of acute myocardial infarction. With the new Troponin-Assays minimal troponin concentration can be detectable. This makes the interpretation of a positive test very difficult, taking to consideration the wide variety of causes of troponin release. The aim of this study is to assess the quality criteria of the troponin test in the diagnosis of acute myocardial infarction in everyday life and asses the influence of leading symptom on the quality criteria of the test. Methods This is a retrospective cross-sectional study, patients, who presented themselves in the emergency department of the Klinikum Lippe-Detmold between 01.01.2014 and 31.05.2014, and had a Troponin-I test, were included. The diagnosis “acute myocardial infarction” referred to myocardial infarction type I and was made by the cardiologist on-duty. The patients were divided into four subgroups according to their leading symptoms. The quality criteria of the Troponin-test were calculated.Results 1046 patients were included. In 15%, acute myocardial infarction was present, of which 97% had thoracic pain. The sensitivities and the negative predictive values were over 90%. The specificities ranged between 56% and 81%. The positive predictive values were modest and best in case of thoracic pain 58%.Conclusion The Troponin test had a good negative predictive value for all clinical symptoms. Thus, an acute myocardial infarction could be excluded with high precision. However, the positive predictive value was low. The only direct symptom that achieved acceptable levels was thoracic pain.$yLinzenz