Combs, Stephanie
[Author];
Rieken, Stefan
[Author];
Wick, Wolfgang
[Author];
Abdollahi, Amir
[Author];
Deimling, Andreas von
[Author];
Debus, Jürgen
[Author];
Hartmann, Christian
[Author]
Prognostic significance of IDH-1 and MGMT in patients with glioblastoma
Description:
A group of 160 patients with primary glioblastoma treated with radiotherapy and temozolomide was analyzed for the impact of O6-methly-guanly-methyl-transferase (MGMT)-promoter methylation as well as isocitrate dehydrogenase (IDH)1-mutational status. Unexpectedly, overall survival or progression-free survival were not longer in the group with methylated MGMT-promoter as compared to patients without that methylation. IDH-1 mutations were significantly associated with increased overall survival.