Published:
[Erscheinungsort nicht ermittelbar]: eScholarship, University of California, 2018
Language:
English
Origination:
University thesis:
Dissertation, eScholarship, University of California, 2018
Footnote:
Description:
Smart" polymers are polymers that respond to certain external stimuli. Specifically, pH- and temperature-responsive polymers have been explored extensively for cancer drug delivery. However, pH-responsive polymers do not provide adequate specificity for tumors, and temperature-responsive polymers do not sufficiently differentiate cancerous and healthy cells. Alternatively, we have been engineering polymers that respond to the Warburg effect. The Warburg effect describes cancer cells' preference in generating energy through aerobic glycolysis instead of oxidative phosphorylation