Characterization and identification of MRNA differentially recruited into polysomes according to CDK1/cycline B activity ; Caractérisation et identification d'ARNms différentiellement recrutés dans les polysomes en fonction de l'activité du complexe CDK1/cycline B
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Media type:
E-Book
Title:
Characterization and identification of MRNA differentially recruited into polysomes according to CDK1/cycline B activity ; Caractérisation et identification d'ARNms différentiellement recrutés dans les polysomes en fonction de l'activité du complexe CDK1/cycline B
imprint:
[Erscheinungsort nicht ermittelbar]: HAL CCSD, 2004
Language:
French
Origination:
University thesis:
Dissertation, HAL CCSD, 2004
Footnote:
Description:
CD complex K1 / cyclin B plays a central role in the organization and performance of the M phase of the cell cycle. changes in the activity were observed in tractuctionnelle parallel activation of CDK1. Thus the overall proétique synthesis is inhibited in M phase in many cell types. However the translation of specific messenger is maintained or increased. In addition to the temporal correlation between the changes and the activity of CDK1, CDK1 certain targets are involved in the translation machinery. Secondly, a role of CDK1 in the synthesis of specific proteins has been shown during meiotic maturation of Xenopus oocyte. We therefore studied the role of CDK1 in the regulation of translational activity and particularly on the recruitment of messengers in polysomes. we showed that CDK1 activity increases recruitment messengers clones corresponding to 28, A8 and 6 while decreasing that of R1 and D2 clones. these results, in accordance with various bibliographic data suggest that CDK1 participates in the overall proétique synthesis inhibition in M phase and is also involved in the maintenance of the synthesis of specific proteins in M phase synthesis of these specific proteins in phase M may be necessary for the proper completion of mitosis. Indeed, messengers 28 and A8 respectively encode a cyclin A and a counterpart NIMA related Kinases", molecules involved in cell cycle regulation. This work to obtain models messengers, will study the regulatory mechanisms dependent translational CDK1. On the other hand, the discovery of these mechanisms will identify new targets CDK1, potential sources of therapeutic intervention.