imprint:
[Erscheinungsort nicht ermittelbar]: [Verlag nicht ermittelbar], 2015
Language:
English
Origination:
University thesis:
Dissertation, 2015
Footnote:
Description:
Abstract Transfusion-related acute lung injury (TRALI) is a serious complication of blood transfusion, which causes serious morbidity and is the leading cause of transfusion-associated mortality according to the FDA. The majority of TRALI cases (up to 89%) are thought to be antibody-mediated TRALI, caused by the passive infusion of white blood cell (WBC)- reactive antibodies, present in plasma-containing blood products. This thesis focuses on the role of donor WBC-reactive antibodies in TRALI, and the translation to preventive strategies.