Network Meta-Analysis and Head and Neck Cancer : Added Value of Analyzing Several Endpoints ; Méta-analyse en réseau et cancer ORL : utilité des critères de jugement multiples
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Media type:
E-Book
Title:
Network Meta-Analysis and Head and Neck Cancer : Added Value of Analyzing Several Endpoints ; Méta-analyse en réseau et cancer ORL : utilité des critères de jugement multiples
Published:
[Erscheinungsort nicht ermittelbar]: HAL CCSD, 2020
Language:
French
Origination:
University thesis:
Dissertation, HAL CCSD, 2020
Footnote:
Description:
Locally advanced head and neck cancers, whether classical" squamous cell carcinomas or undifferentiated carcinomas of the nasopharynx, are treated by multimodality therapy. Loco-regional treatment is the main therapy, with surgery and/or radiotherapy. This radiotherapy can be standard (66-70 Grays in 33-35 fractions) or can have a modified fractionation (hyperfractionation or acceleration). Chemotherapy is often associated to these treatments, with different timing: induction, concomitant or adjuvant.Several randomized trials have compared different combinations of treatments. A network meta-analysis allows performing a pooled analysis of all these randomized trials, using the direct and indirect information available to determine the relative efficacy of the treatments.The objective of this doctoral thesis was to perform frequentist network meta-analyses using individual patient data from three standard meta-analyses:- combination of two meta-analyses for squamous cell carcinomas (MACH-NC and MARCH, 115 trials