Sinteza i antiproliferativna aktivnost novih D-homo i D-seko derivata androstana ; Synthesis and antiproliferative activity of new D-homo and D-seco androstane derivatives
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Media type:
E-Book
Title:
Sinteza i antiproliferativna aktivnost novih D-homo i D-seko derivata androstana ; Synthesis and antiproliferative activity of new D-homo and D-seco androstane derivatives
imprint:
[Erscheinungsort nicht ermittelbar]: Универзитет у Новом Саду, Природно-математички факултет, 2020
Origination:
University thesis:
Dissertation, Универзитет у Новом Саду, Природно-математички факултет, 2020
Footnote:
Description:
U prvom delu ove doktorske disertacije je izvršena sinteza novih derivata androstana sa D-laktonskom funkcijom ili D-seko derivata, sa modifikacijama u Ai/ ili B-prstenovima. U drugom delu je ispitana antiproliferativna aktivnost odabranih novosintetizovanih jedinjenja prema humanim tumorskim ćelijskim linijama (MCF-7, MDA-MB-231, PC-3, HeLa, HT-29, K562) kao i prema zdravim ćelijama fetalnih fibroblasta pluća (MRC-5). ; In first part of this work was achieved synthesis of some new androstane derivatives with D-lactone function and new D-seco derivatives with modification in A and/or B rings. In the second part the antiproliferative activity of selected newly synthesized compounds by human carcinoma cell lines (MCF-7, MDA-MB-231, PC-3, HeLa, HT-29, K562) and the healthy cells of fetal lung fibroblasts (MRC-5 ) was examined.