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Ji, Haiwei [Author]; Liu, Xiaodi [Author]; Hu, Haolu [Author]; Tang, Qu [Author]; Kang, Xiaoxia [Author]; Zhao, Lingfeng [Author]; Wu, Mingmin [Author]; Li, Guo [Author]; Zhou, Xiaobo [Author]; Liu, Jinxia [Author]; Wang, Qi [Author]; Wu, Li [Author]; Qin, Yuling [Author]

Precisely Controlled and Deeply Penetrated Micro-Nano Hybrid Multifunctional Motors with Enhanced Antibacterial Activity Against Refractory Biofilm Infections

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  • Media type: E-Book
  • Title: Precisely Controlled and Deeply Penetrated Micro-Nano Hybrid Multifunctional Motors with Enhanced Antibacterial Activity Against Refractory Biofilm Infections
  • Contributor: Ji, Haiwei [VerfasserIn]; Liu, Xiaodi [VerfasserIn]; Hu, Haolu [VerfasserIn]; Tang, Qu [VerfasserIn]; Kang, Xiaoxia [VerfasserIn]; Zhao, Lingfeng [VerfasserIn]; Wu, Mingmin [VerfasserIn]; Li, Guo [VerfasserIn]; Zhou, Xiaobo [VerfasserIn]; Liu, Jinxia [VerfasserIn]; Wang, Qi [VerfasserIn]; Wu, Li [VerfasserIn]; Qin, Yuling [VerfasserIn]
  • imprint: [S.l.]: SSRN, [2022]
  • Extent: 1 Online-Ressource (28 p)
  • Language: English
  • DOI: 10.2139/ssrn.4016031
  • Identifier:
  • Origination:
  • Footnote:
  • Description: The biofilm resistance of microorganisms has severe economic and environmental implications, especially the contamination of facilities associated with human life, including medical implants, air-conditioning systems, water supply systems, and food-processing equipment, resulting in the prevalence of infectious diseases. In order to overcome the contamination of bacterial biofilm, destroying the biofilm’s matrix so as to solve the penetration depth dilemma of antibacterial agents is the most effective way. Here, a magnetically controlled multifunctional micromotor was developed by using H 2 O 2 as the fuel and MnO 2 as the catalyst to treat bacterial biofilm infection. In the presence of H 2 O 2 , the as-prepared motors could be self-propelled by the generated oxygen microbubbles. Thereby, the remotely controlled motors could drill into the EPS of biofilm and disrupt them completely with the help of bubbles. Finally, the generated highly toxic •OH could efficiently kill the unprotected bacteria. This strategy combined the mechanical damage, highly toxic •OH, and precise magnetic guidance in one system, which could effectively eliminate biologically infectious fouling in microchannels within 10 minutes, possessing a wide range of practical application prospects especially in large scale and complex infection sites
  • Access State: Open Access