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Oehler, Daniel [Author]; Spychala, André [Author]; Gödecke, Axel [Author]; Lang, Alexander [Author]; Gerdes, Norbert [Author]; Ruas, Jorge [Author]; Kelm, Malte [Author]; Szendrödi, Julia [Author]; Westenfeld, Ralf [Author]

Full-length transcriptomic analysis in murine and human heart reveals diversity of PGC-1α promoters and isoforms regulated distinctly in myocardial ischemia and obesity

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  • Media type: E-Article
  • Title: Full-length transcriptomic analysis in murine and human heart reveals diversity of PGC-1α promoters and isoforms regulated distinctly in myocardial ischemia and obesity
  • Contributor: Oehler, Daniel [Author]; Spychala, André [Author]; Gödecke, Axel [Author]; Lang, Alexander [Author]; Gerdes, Norbert [Author]; Ruas, Jorge [Author]; Kelm, Malte [Author]; Szendrödi, Julia [Author]; Westenfeld, Ralf [Author]
  • Published: 30 July 2022
  • Published in: BMC biology ; 20(2022), Artikel-ID 169, Seite 1-20
  • Language: English
  • DOI: 10.1186/s12915-022-01360-w
  • Identifier:
  • Keywords: Diet-induced obesity ; Ischemia/reperfusion ; Long-read sequencing ; PGC-1α
  • Origination:
  • Footnote:
  • Description: Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) acts as a transcriptional coactivator and regulates mitochondrial function. Various isoforms are generated by alternative splicing and differentially regulated promoters. In the heart, total PGC-1α deficiency knockout leads to dilatative cardiomyopathy, but knowledge on the complexity of cardiac isoform expression of PGC-1α remains sparse. Thus, this study aims to generate a reliable dataset on cardiac isoform expression pattern by long-read mRNA sequencing, followed by investigation of differential regulation of PGC-1α isoforms under metabolic and ischemic stress, using high-fat-high-sucrose-diet-induced obesity and a murine model of myocardial infarction.
  • Access State: Open Access