University thesis:
Dissertation, Georg-August-Universität Göttingen, 2021
Footnote:
Description:
While memory formation is traditionally linked to changes in synaptic structure, the transcriptional processes enabling these changes are often understudied. Even though novel protein synthesis is the basis of long-term memory formation, the exact interplay between synaptic stimulation and transcriptional regulation remain elusive. In a former study, the Fischer lab could show that changes in the epigenetic code, one of the regulators of transcription, can be directly linked to memory performance in mice. The manipulation of this code via the inhibition of proteins that actively change it b...