Grimm, Nikolai
[Author]
;
Lotze, Martin
[Degree supervisor];
Teipel, Stefan
[Degree supervisor]Universität Greifswald
Veränderungen der grauen Substanz des Gehirns bei craniomandibulärer Dysfunktion (CMD) bei einer Populationskohorte und drei klinischen Probandengruppen
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Media type:
E-Book;
Thesis
Title:
Veränderungen der grauen Substanz des Gehirns bei craniomandibulärer Dysfunktion (CMD) bei einer Populationskohorte und drei klinischen Probandengruppen
Temporomandibular pain is a common symptom consisting of pain localised around the joint portion of the jaw with a strong dependence on stressors. Chronic pain has been associated with changes in brain grey matter volume (GMV). However, previous studies on this topic have shown contradictory results. Among other things this may be due to the different formation of the study populations and the underlying study methods. In order to investigate the effects of chronic pain on brain structure with a high number of cases, the present study analysed three groups of clinical patients, a total of 47 individuals, and a study population consisting of a total of 57 patients who reported facial pain over the last 6 months. The patients of the study population were recruited from the Study of Health in Pomerania (SHIP), the patients of the clinical subject groups in cooperation with the Greifswald Dental Clinic. The grey matter volume of these patients was compared in each case with that of a healthy control group without chronic pain. The control group consisted of 60 individuals for comparing the clinical patients and 381 individuals for comparing the patients of the study population. Both control groups were corrected for age and gender. For brain structure analysis, voxel-based morphometry was used as a popular in vivo method. For this purpose, the patients and the control subjects received an MRI. In a region of interest analysis, only the clinical patient group showed a reduced grey ...