Haylock, Michael
[Author];
Kampkötter, Patrick
[Author];
Macis, Mario
[Author];
Sauter, Jürgen
[Author];
Seitz, Susanne
[Author];
Slonim, Robert
[Author];
Wiesen, Daniel
[Author];
Schmidt, Alexander H.
[Author]
Improving the Availability of Unrelated Stem Cell Donors
: Evidence from a Major Donor Registry
Description:
The unavailability of potential stem cell donors poses a critical challenge for donor registries worldwide. This study investigates the impact of initiatives of a stem cell donor registry to enhance donors' availability for confirmatory typing. Initiatives ask donors to provide a sample for genetic analysis and/or information on their temporal unavailability. We analyzed 91,479 confirmatory typing requests from DKMS Germany, a large stem cell donor registry, exploiting a quasi-random initiative assignment based on observable characteristics. We find that, first, invitation to the initiatives increases donors' availability. Intention-to-treat estimates yield effects ranging from 2.5 to 3.2 percentage points, and local average treatment effects estimates range from 3.8 to 8.2 percentage points (baseline: 77.1%). Second, the difference in availability between participants and non-participants is over 10 percentage points. The initiatives yield a direct positive effect on donor availability and a selection effect through which participation signals a higher commitment