Objective: Edema and subjective leg complaints, such as pain, tightness, tiredness and heaviness after long standing or sitting, are defined as orthostatic leg complaints or occupational edema. Compression hosiery should help to prevent or decrease those symptoms. The objective was to assess the effects on leg discomforts and leg volume, and wearing comfort in two medical below-knee compression stocking types with an interface pressure of 18 – 20 mmHg (A vs. B) and a below-knee-low-pressure support stocking (LPSS) with an interface pressure of 8-10mmHg (C). Methods: Two different types of below-knee medical compression stockings with an interface pressure of 18 – 20 mmHg (A vs. B) and a below-knee-low-pressure support stocking (LPSS) with an interface pressure of 8-10mmHg (C) were examined in this randomized, blinded, crossover trial (RCT) with 49 healthy volunteers having leg discomforts and edema after being in an upright position during the day. Stocking Type B had special fabrication properties in the in heel and instep-area of the foot. Participants were divided into two cohorts, and each type of stocking was worn for three consecutive days in one week with a subsequent washout phase. The cohorts were named after the respective sequence of the wearing period (ABC/BAC). The assessment of effects and wearing comfort was ascertained by questionnaires. Volume changes in the lower leg were measured with the Bodytronic 600® (Bauerfeind AG, Zeulenroda, Germany). Results: A ...